113933-52-1

Basic information

• Product Name: ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(1-hydroxyprop-2-ylamino)acrylate
• Synonyms: ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(1-hydroxyprop-2-ylamino)acrylate
• CAS NO: 113933-52-1
• Molecular Weight: 349.282
• Mol File: 113933-52-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(1-hydroxyprop-2-ylamino)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(1-hydroxyprop-2-ylamino)acrylate(113933-52-1)
• EPA Substance Registry System: ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(1-hydroxyprop-2-ylamino)acrylate(113933-52-1)

Safety Data

• Hazardous Substances Data: 113933-52-1(Hazardous Substances Data)

Upstream product

• 6168-72-5 2-Amino-1-propanol 
• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
• 122-51-0 orthoformic acid triethyl ester 
• 103994-82-7 ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 
• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 

Downstream Products

• 82419-36-1 ofloxacin 
• 82419-35-0 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid 
• 82419-34-9 ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate 
• 107359-16-0 ethyl 6,7,8-trifluoro-1,4-dihydro-1-(1-hydroxyprop-2-yl)-4-oxoquinoline-3-carboxylate 

Relevant articles and documents

Improved method of preparation process of oxo-fluoro cyclization ester or levo-oxo-fluoro cyclization ester

The invention discloses an improved method of a preparation process of oxo-fluoro cyclization ester or levooxo-fluoro cyclization ester. Existing preparation methods of some levofloxacin intermediateshave many side reactions and are low in yield. According to the technical scheme in the invention, by means of 2,3,4,5-tetrafluorobenzoyl chloride, N,N-dimethylaminoethyl acrylate and (L-)aminopropanol as starting raw materials and toluene and N, N-dimethylformamide added with a water removal agent organic ester or anhydride as solvents, the oxygen-fluorine cyclization ester is prepared through aone-pot reaction. According to the method, organic ester or anhydride is added, so that the loss of raw materials and the generation of by-products are reduced, the reaction yield is increased, the product quality is ensured, and the yield of the (L-)oxo-fluoro cyclization ester can be increased from 75-80% to about 90%.

Antibacterial 1,8-bridged 4-quinolone-3-carboxylic acids

A process for the preparation of a 1,8-bridged 4-quinolone-3-carboxylic acid of the formula STR1 wherein the substituents are defined hereinbelow. Some of the compound are new. The old and new compounds are antibacterials and promote animal growth.