80858-95-3

Upstream product

• 36112-61-5 6-methoxy-1-naphthoic acid 
• 115375-59-2 6-methoxy-3,4-dihydronaphthalene-1-yl triflate 
• 80859-07-0 6-methoxy-1-(trimethylsilanyloxy)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile 
• 100-66-3 methoxybenzene 
• 88-14-2 2-furanoic acid 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 83390-26-5 6-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carbaldehyde 
• 113967-27-4 methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylate 
• 198068-77-8 6-methoxy-3,4-dihydro-[1]naphthoic acid 

Downstream Products

• 1459789-88-8 N-(2-bromophenyl)-6-methoxy-N-methyl-1,2,3,4-tetrahydronaphthalene-1-carboxamide 
• 113967-27-4 methyl 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylate 

Relevant academic research and scientific papers

AMINOTRIAZOLE IMMUNOMODULATORS FOR TREATING AUTOIMMUNE DISEASES

1-Acyl-3-(heteroaryl)-1H-1,2,4-triazol-5-amines of formula (I) are disclosed. These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.

Asymmetric pericyclic cascade approach to spirocyclic oxindoles

The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.

1,9-ALKANO-BRIDGED-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES

1,9-Alkano-bridged-2,3,4,5-tetrahydro-1H-3-benzazepines and the derivatives thereof, i.e., the compounds of Formula I: STR1 wherein: R is selected from the group consisting of: hydrogen, cyano, lower alkyl, lower alkenyl, and aralkyl;each of R 1, R 2 and R 3 is independently selected from the group consisting of: hydrogen, hydroxy, halo, trifluoromethyl, nitro, amido, lower alkoxy, lower alkyl, and lower alkylthio; andY is lower alkylene having from two to four carbon atoms;and the pharmaceutically acceptable salts thereof, are useful as CNS agents, e.g., as antidepressants, anxiolytics and antihypertensives, and/or as precursors thereto.

Synthesis of Tricyclospirodienones via Spiroannulation; Methodology for Synthesis of Aromatase Inhibitors

A new approach to the title ring system, required for the development of potential aromatase inhibitors, is described; acid chlorides (6) and (12) undergo an unusual addition-cyclisation reaction with alkynes, catalysed by aluminium chloride, to yield tri

Lewis Acid-Promoted Favorskii-Type Ring Contraction of Some Cyclic α-Bromo Ketones and Their Acetals

The α-bromo cycloalkyl aryl ketones 2a-d on heating with zinc chloride in methanol furnished in moderate to good yields the ring-contracted products 3a-d having gem methyl carbomethoxy function.The acetals of the related α-bromo ketones 7a-c, lacking the methyl group on the halogen-bearing carbon atom, afforded in acceptable yields the ring-contracted esters 8a-c when heated in protic solvent.The limitation of the present ring-contraction procedure has been discussed.