1140067-25-9

Basic information

• Product Name: 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine
• Synonyms: 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine
• CAS NO: 1140067-25-9
• Molecular Weight: 358.44
• Mol File: 1140067-25-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine(1140067-25-9)
• EPA Substance Registry System: 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine(1140067-25-9)

Safety Data

• Hazardous Substances Data: 1140067-25-9(Hazardous Substances Data)

Upstream product

• 13472-00-9 p-Aminophenethylamine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 40377-41-1 4-(2-(((methyl)carbonyl)amino)ethyl)aniline 

Downstream Products

• 1139884-43-7 4-(2-aminoethyl)-N-(9-fluorenylmethoxycarbonyl)phenylamine hydrochloride 

Relevant articles and documents

METHOD FOR CLEAVING AMIDE BONDS

A method for cleaving amide bonds, comprising: a) providing a molecule comprising an amide group;b) reacting the molecule comprising an amide group with hydroxylamine (NH2OH) or a salt thereof to cleave the amide bond of the amide group.

Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection

Primary amines can be readily doubly protected as N-substituted 2,5-dimethylpyrroles. Although this protecting group is stable toward strong bases and nucleophiles, long reaction times are required for both the protection and deprotection steps, generally resulting in low deprotection yields. By employing microwave irradiation, protection and deprotection reaction times are dramatically reduced. Furthermore, deprotection with dilute hydrochloric acid in ethanol increases reaction yields. Diverse deprotection conditions have been developed in conjunction with microwave irradiation, so that protection as an N-substituted 2,5-dimethylpyrrole can be orthogonal to other standard amine protecting groups, such as tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).