114071-49-7

Basic information

• Product Name: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-hydroxy-6'-carba-β-D-ribofuranosyl)thymine
• Synonyms: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-hydroxy-6'-carba-β-D-ribofuranosyl)thymine
• CAS NO: 114071-49-7
• Molecular Weight: 436.508
• Mol File: 114071-49-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-hydroxy-6'-carba-β-D-ribofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-hydroxy-6'-carba-β-D-ribofuranosyl)thymine(114071-49-7)
• EPA Substance Registry System: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-hydroxy-6'-carba-β-D-ribofuranosyl)thymine(114071-49-7)

Safety Data

• Hazardous Substances Data: 114071-49-7(Hazardous Substances Data)

Upstream product

• 4984-82-1 sodium cyclopentadienylide 
• 3587-60-8 Benzyloxymethyl chloride 
• 65-71-4 2,4-dihydroxy-5-methylpyrimidine 
• 129436-48-2 (5aS,7S,8R,8aR)-7-Benzyloxy-8-benzyloxymethyl-3-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]oxazolo[3,2-a]pyrimidin-2-one 
• 110567-21-0 (1S,2R)-2-(benzyloxymethyl)-1-hydroxy-3-cyclopentene 
• 117641-39-1 (2R,3S)-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexan-3-ol 
• 542-92-7 cyclopenta-1,3-diene 
• 39939-07-6 5-(benzyloxymethyl)cyclopentadiene 
• 110567-22-1 (2R,3S)-benzyloxy-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexane 
• 65-71-4 thymin 

Downstream Products

• 129436-49-3 1-((1S,4S)-4-Benzyloxy-3-benzyloxymethyl-cyclopent-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 129436-50-6 1-((3R,4S)-4-Benzyloxy-3-benzyloxymethyl-cyclopent-1-enyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 142217-83-2 1-((1S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-methylene-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 648414-58-8 1-(3',5'-di-O-benzyl-2'-deoxy-6'-carba-β-D-ribofuranosyl)thymine 
• 114884-15-0 1-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 142217-82-1 1-((1S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-oxo-cyclopentyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 129436-48-2 (5aS,7S,8R,8aR)-7-Benzyloxy-8-benzyloxymethyl-3-methyl-6,7,8,8a-tetrahydro-5aH-cyclopenta[4,5]oxazolo[3,2-a]pyrimidin-2-one 

Relevant articles and documents

New convergent synthesis of carbocyclic nucleoside analogues

Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSalpronucleotide and the corresponding nucleotide will be presented for one example.

Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines

Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts.

Short Convergent Route to Homochiral Carbocyclic 2'-Deoxynucleosides and Carbocyclic Ribonucleosides

The epoxide (1) has been converted into the antiviral agents (5) and (7) while epoxide (9) furnished carbocyclic guanosine (12).