114151-49-4

Basic information

• Product Name: 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride
• Synonyms: 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride
• CAS NO: 114151-49-4
• Molecular Weight: 375.254
• Mol File: 114151-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride(114151-49-4)
• EPA Substance Registry System: 3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-propionyl chloride(114151-49-4)

Safety Data

• Hazardous Substances Data: 114151-49-4(Hazardous Substances Data)

Upstream product

• 114150-42-4 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid 
• 111881-78-8 6-(4-chlorophenyl)-4,6-dioxohexanoic acid 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 

Downstream Products

• 103475-41-8 tepoxalin 

Relevant articles and documents

The regioselective synthesis of tepoxalin, 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-me thylpropanamide and related 1,5-diarylpyrazole anti-inflammatory agents

Tepoxalin, a potent anti-inflammatory agent, and its analogs can be synthesized by condensing an appropriate arylhydrazine hydrochloride and a 6-aryl-4,6-dioxohexanoic acid in alcohol with a base catalyst. These diarylpyrazolylpropanoic acids can be converted to their N-methylhydroxamic acids by generating the requisite acid chloride, and allowing it to react with N-methylhydroxylamine.