103475-41-8 Usage
Chemical Properties
Off-White Solid
Uses
Different sources of media describe the Uses of 103475-41-8 differently. You can refer to the following data:
1. Tepoxalin is non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic properties approved for veterinary use. It has inhibitory effect on cyclooxygenase and 5-lipxygenase activity a s well as inhibiting the production of cytokines in peripheral cells outside the CNS.
2. Non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic properties approved for veterinary use. It has inhibitory effect on cyclooxygenase and 5-lipxygenase activity as well as inhibiting the production of cytokines in peripheral cells outside the CNS.
Definition
ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]propanoic acid with the amino group of N-methylhydroxylamine. It is used in veterinary medicine for the contr
l of pain and inflammation caused by musculoskeletal disorders such as hip dysplasia and arthritis in dogs.
Veterinary Drugs and Treatments
Tepoxalin is indicated for the treatment of pain and inflammation
associated with osteoarthritis in dogs. Because of the drug’s inhibitory
effects on leukotrienes, there is interest in seeing if it would
be beneficial in the adjunctive treatment of allergic conditions in
dogs.
Check Digit Verification of cas no
The CAS Registry Mumber 103475-41-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,7 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 103475-41:
(8*1)+(7*0)+(6*3)+(5*4)+(4*7)+(3*5)+(2*4)+(1*1)=98
98 % 10 = 8
So 103475-41-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
103475-41-8Relevant articles and documents
Process for preparing 1,5-diaryl-3-substituted pyrazoles
-
, (2008/06/13)
A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
A Facile Synthesis of Tepoxalin, 5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide
Murray, William V.,Hadden, Susan K.
, p. 6662 - 6663 (2007/10/02)
-
Regioselective synthesis of a 1,5-disubstituted pyrazole
-
, (2008/06/13)
A highly regioselective synthesis of pyrazoles from a mono-substituted hydrazine and a β-dicarbonyl compound wherein a carboxylic acid moiety is present on the substituent attached to one of the carbonyls. For example, compounds of the formula (I) are formed in marked preference to isomers of formula (IV): STR1