1142-41-2Relevant academic research and scientific papers
Fluorescence sensing due to allosteric switching of pyrene functionalized cis-cyclohexane-1,3-dicarboxylate
Monahan, Carol,Bien, Jeffrey T.,Smith, Bradley D.
, p. 431 - 432 (2007/10/03)
The excimer/monomer fluorescence ratio for a pyrene functionalized cis-cyclohexane-1,3-dicarboxylate decreases upon titration with divalent and monovalent metal cations, as well as strong and weak acids.
Mechanism of Stereospecific Alcohol Elimination from Cyclohexane trans-1,3-Dicarboxylates Under Electron Impact Ionization
Etinger, A.,Idina, A.,Madelbaum, A.
, p. 342 - 346 (2007/10/02)
Diesters of cyclohexane trans-1,3-dicarboxylic acid give rise to major (+.) ions under electron impact ionization.A mass spectral study of the isomeric mixed methyl ethyl esters of the diacid, substituted by a methyl group at position 1 and deuterium labelled at position 3, indicates a stepwise mechanism for this alcohol elimination; the 3-hydrogen (or deuterium) is transferred to the carbonyl of the 1-ester group in the initial step.Subsequent migration of that hydrogen (or deuterium) to the alkoxyl of position 3 results in the highly site- and stereospecific alcohol elimination.CID spectra of the (+.) ions obtained from the stereoisomeric diesters clearly show that they have different structures (or are different mixtures of structures).
Remote Enzyme-Coupled Amine Release
Menger, F. M.,Ladika, M.
, p. 3006 - 3007 (2007/10/02)
A remote enzyme-coupled amine release system has been developed in which biochemical and chemical "demasking" processes are sequentially linked via an enforced 1,3-diaxial disposition.Thus, pig liver esterase hydrolyzes an ester to an acid, and the acid promotes a fast intramolecular cleavage of an amide to an amine.The sequence has potential pharmacokinetic relevance because it allows enzyme-specific discharge of amine-based drugs following their trans-membrane journey as uncharged amides.
