27768-32-7

Basic information

• Product Name: 1,3-Cyclohexanedicarbonyl dichloride (9CI)
• Synonyms: 1,3-Cyclohexanedicarbonyl dichloride (9CI)
• CAS NO: 27768-32-7
• Molecular Formula: C₈H₁₀Cl₂O₂
• Molecular Weight: 209.0698
• Product Categories: ACIDHALIDE
• Mol File: 27768-32-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Cyclohexanedicarbonyl dichloride (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Cyclohexanedicarbonyl dichloride (9CI)(27768-32-7)
• EPA Substance Registry System: 1,3-Cyclohexanedicarbonyl dichloride (9CI)(27768-32-7)

Safety Data

• Hazardous Substances Data: 27768-32-7(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Solubility

Insoluble in water, soluble in organic solvents

Uses

Intermediate in the production of dyes and pigments
Synthesis of pharmaceuticals and agrochemicals
Production of polymer resins
Chemical intermediate in the manufacture of other organic compounds

Health hazards

Respiratory irritant, potential skin and eye irritation

Safety precautions

Handle with caution due to irritant properties

Upstream product

• 121-91-5 isophthalic acid 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 

Downstream Products

• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 1135-56-4 1,3-Dimethylcyclohexan-1,3-dicarbonsaeure 
• 1142-41-2 dimethyl ester of cis-1,3-dimethylcyclohexane-1,3-dicarboxylic acid 
• 127183-15-7 (1S,3R)-1,3-Dimethyl-3-(pyrrolidine-1-carbonyl)-cyclohexanecarboxylic acid cyanomethyl ester 

Relevant articles and documents

Novel bivalent securinine mimetics as topoisomerase I inhibitors

A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitory activity three times that of parent securinine. Comprehensive structure-activity relationship analyses in combination with docking studies were used to rationalize the potent activity of these bivalent mimetics. Mechanistic studies served to confirm the deductions arising from docking studies that the active bivalent mimetics not only inhibited complexation between Topo I and DNA but also stabilized the Topo I-DNA complex itself.

Remote Enzyme-Coupled Amine Release

A remote enzyme-coupled amine release system has been developed in which biochemical and chemical "demasking" processes are sequentially linked via an enforced 1,3-diaxial disposition.Thus, pig liver esterase hydrolyzes an ester to an acid, and the acid promotes a fast intramolecular cleavage of an amide to an amine.The sequence has potential pharmacokinetic relevance because it allows enzyme-specific discharge of amine-based drugs following their trans-membrane journey as uncharged amides.