1142-99-0

Upstream product

• 824-79-3 sodium 4-methylbenzenesulfinate 
• 140-88-5 ethyl acrylate 
• 539-74-2 Ethyl 3-bromopropionate 
• 111047-53-1 methyl 2-((4-methylphenyl)sulfonamido)-2-phenylacetate 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 1593-60-8 p-toluenesulfonylhydroxylamine 
• 40939-26-2 {[(4-methylphenyl)sulfonyl]methyl}carbonimidic dichloride 

Relevant academic research and scientific papers

Development of a Synthetic Method for Multifunctionalized Pyrroles Using Isocyanide Dichloride as a Key Intermediate

Multifunctionalized pyrrole derivatives were synthesized using a highly efficient method based on the Michael addition of carbanions generated in situ from isocyanide dichloride to α,β-unsaturated carbonyl compounds. The reactions proceeded smoothly to afford the pyrrole derivatives in good to high yields. A wide range of Michael acceptors, such as α,β-unsaturated carbonyl compounds and nitroolefin, were successfully applied to this reaction.

A green and novel method for synthesis of β-sulfonyl esters under solvent-free conditions

A manipulative simple and efficient green methodology for the synthesis of β-sulfonyl esters from sulfonyl hydrazides and acrylic esters promoted by DABCO (1,4-diazabicyclo[2.2.2]octane) is described. The reaction is conducted through sulfa-Michael addition reaction in the absence of solvent at 75°C within 2–3 h. The effects of different bases, molar ratio of DABCO, temperature and time parameters on yield of reaction were investigated.

Synthesis of alkyl aryl sulfones via reaction of N-arylsulfonyl hydroxyamines with electron-deficient alkenes

Alkyl aryl sulfones were prepared in high yields via the reaction of N-arylsulfonyl hydroxylamines with electron-deficient alkenes. These reactions have the advantages of simplicity, easily available starting materials and mild reaction conditions.

Method for preparing substituted ethyl aryl sulfone

The invention discloses a method for preparing substituted ethyl aryl sulfone. The method comprises the following steps: a compound shown in a formula II, a compound shown in a formula III and alkali are uniformly mixed in a solvent and are subjected to a coupling reaction, a compound shown in a formula I containing R2' as -CH2CH2R is obtained after the reaction is complete; or the method comprises the following steps: the compound shown in the formula II, ethyl propiolate and alkali are uniformly mixed in the solvent and then are subjected to the coupling reaction, and the compound shown in a formula I containing R2' as -CH=CH2=OOCH2CH3 is obtained after the reaction is complete. The method has the advantages of universality, convenience, simple reaction system, and mild reaction condition; the reaction can be amplified to a gram level, the reaction raw materials are simple and easily available, the used alkali and raw materials have the advantages of low cost and easy acquisition, the atom utilization rate is high, and solvent toxicity is low.

Catalyst-free sulfonylation of activated alkenes for highly efficient synthesis of mono-substituted ethyl sulfones in water

A catalyst-free sulfonylation reaction of activated alkenes with sulfonyl hydrazides was efficiently developed under mild and environmentally benign conditions, in water without any ligand or additive. The reaction gave a range of structurally diverse mono-substituted ethyl sulfones with excellent yields, in which the by-product was nitrogen. the Partner Organisations 2014.

A simple and rapid preparation of sulfones from alkyl halides using ultrasound

Appropriate alkyl halides and sodium p-toluenesulfinates react rapidly in DMF-water at room temperature under the influence of ultrasound to afford sulfones. Using this procedure a wide variety of sulfones have been prepared.