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Ethanone, 1-[2,4-bis(1,1-dimethylethyl)phenyl]-, also known as 1-[2,4-bis(tert-butyl)phenyl]ethanone or 2,4-bis(tert-butyl)acetophenone, is an organic compound with the chemical formula C14H22O. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. Ethanone, 1-[2,4-bis(1,1-dimethylethyl)phenyl]- is characterized by its two tert-butyl groups (1,1-dimethylethyl) attached to the 2 and 4 positions of a phenyl ring, with an acetone group (ethanone) attached to the 1 position. It is commonly used as a chemical intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Due to its stability and reactivity, it is also employed in the preparation of antioxidants and UV stabilizers for polymers.

1144-40-7

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1144-40-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1144-40-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1144-40:
(6*1)+(5*1)+(4*4)+(3*4)+(2*4)+(1*0)=47
47 % 10 = 7
So 1144-40-7 is a valid CAS Registry Number.

1144-40-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-di-tert-butylacetophenone

1.2 Other means of identification

Product number -
Other names .2,4-Di-tert-butyl-acetophenon

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1144-40-7 SDS

1144-40-7Relevant academic research and scientific papers

α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model

Gomtsyan, Arthur,Bayburt, Erol K.,Keddy, Ryan,Turner, Sean C.,Jinkerson, Tammie K.,Didomenico, Stanley,Perner, Richard J.,Koenig, John R.,Drizin, Irene,McDonald, Heath A.,Surowy, Carol S.,Honore, Prisca,Mikusa, Joe,Marsh, Kennan C.,Wetter, Jill M.,Faltynek, Connie R.,Lee, Chih-Hung

, p. 3894 - 3899 (2008/02/09)

SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain.

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