114506-04-6

Basic information

• Product Name: (E)-4-Bromo-1-chloro-2-methyl-2-butene
• Synonyms: (E)-4-Bromo-1-chloro-2-methyl-2-butene
• CAS NO: 114506-04-6
• Molecular Formula: C₅H₈BrCl
• Molecular Weight: 183.47402
• Product Categories: Aliphatics;Intermediates;Miscellaneous Reagents;Aliphatics, Intermediates, Miscellaneous Reagents
• Mol File: 114506-04-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 195.8°C at 760 mmHg
• Flash Point: 83.616°C
• Appearance: /
• Density: 1.422g/cm³
• Vapor Pressure: 0.577mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Amber Vial, -86°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Light Sensitive, Moisture Sensitive, Temperature Sensitive
• CAS DataBase Reference: (E)-4-Bromo-1-chloro-2-methyl-2-butene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-Bromo-1-chloro-2-methyl-2-butene(114506-04-6)
• EPA Substance Registry System: (E)-4-Bromo-1-chloro-2-methyl-2-butene(114506-04-6)

Safety Data

• Hazardous Substances Data: 114506-04-6(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

InChI:InChI=1/C5H8BrCl/c1-5(4-7)2-3-6/h2H,3-4H2,1H3/b5-2+

Upstream product

• 7437-62-9 1-chloro-2-methyl-3-buten-2-ol 
• 78-79-5 isoprene 
• 53170-97-1 (E)-4-chloro-3-methyl-2-buten-1-ol 
• 24529-80-4 (E)-1-O-acetyl-4-chloro-3-methyl-2-buten-1-ol 

Downstream Products

• 791102-78-8 ((E)-4-Chloro-3-methyl-but-2-enyloxy)-benzene 
• 1508298-49-4 (S,E)-tert-butyl 2-(N-(4-chloro-3-methylbut-2-enyl)-4-methylphenylsulfonamido)-4,4-dimethoxybutanoate 
• 54910-48-4 squalene 2,3(S)-oxide 
• 791102-87-9 (8R,9S,13S,14S)-3-[(2E,6E,8E)-5-Benzenesulfonyl-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trienyloxy]-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one 
• 791102-88-0 (S)-3-{4-[(2E,6E,8E)-5-Benzenesulfonyl-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trienyloxy]-phenyl}-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 791102-83-5 [(1E,3E,7E)-9-((E)-3,7-Dimethyl-octa-2,6-dienyloxy)-3,7-dimethyl-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-1,3,7-triene-5-sulfonyl]-benzene 
• 791102-86-8 2-[(2E,6E,8E)-5-Benzenesulfonyl-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6,8-trienyl]-isoindole-1,3-dione 
• 791102-84-6 C₃₂H₄₀O₃S 
• 791102-85-7 C₃₂H₄₀O₂S₂ 
• 74193-18-3 retinyl benzamide 
• 68-26-8 RETINOL 
• 75664-68-5 9-Phenoxy-3.7-dimethyl-1t-(2.2.6-trimethyl-cyclohexen-⁽⁶⁾-yl)-nonatetraen-(1.3t.5t.7t) 

Relevant articles and documents

A SHORT AND CONVERGENT ENENTIOSELECTIVE SYNTHESIS OF (3S)-2,3-OXIDOSQUALENE

A very useful synthesis of (3S)-2,3-oxidosqualene from geraniol, farnesol and E-1-bromo-4-chloro-3-methyl-2-butene is described which makes use of enantioselective and catalytic dihydroxylation of geranyl acetate and two E-stereospecific allylic coupling reactions mediated by E-prenylbarium reagents.

Role of Ring Ortho Substituents on the Configuration of Carotenoid Polyene Chains

The 9-(Z)-configuration was exclusively obtained in the carotenoid polyene chain irrespective of olefination and disconnection methods for terminal ortho-unsubstituted benzene rings. The 2,6-dimethyl substituents in the terminal rings secure an all-(E)-po

Highly Efficient and General Synthetic Method of Various Retinyl Ethers

Bromination of 4 by PBr3 under Cu(I) catalyst produces the ambidextrous allylic halide 5 regioselectively and stereoselectively. Hetero nucleophiles distinguish the allylic carbon containing Br from the one containing Cl in 5 to give the heteroatom-substituted C5 allylic chloride 3. The Julia olefination reaction with the C15 sulfone 2 provides diverse retinyl ethers 1.