1145786-23-7

Upstream product

• 1145786-68-0 6-chloro-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine 
• 1145786-45-3 [4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]boronic acid 
• 1145786-44-2 4-methyl-1-[2-(methyloxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazole 
• 870838-56-5 1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole 
• 1145786-47-5 3-chloro-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]pyridazine 
• 64715-85-1 (R)-2-methoxy-1-phenylethylamine 
• 59557-91-4 4-bromo-2-methoxyaniline 
• 791642-68-7 4-bromo-1-iodo-2-methoxybenzene 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1145786-22-6 6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine hydrochloride 

Relevant academic research and scientific papers

Pyridazine-derived γ-secretase modulators

SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25

PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION

The present invention relates to novel compounds that inhibit the production of β- amyloid peptide (1-42), processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.