114610-10-5

Basic information

• Product Name: 1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid
• Synonyms: 1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid
• CAS NO: 114610-10-5
• Molecular Formula: C₁₉H₁₆F₂N₄O₃
• Molecular Weight: 386.35
• Mol File: 114610-10-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 634°Cat760mmHg
• Flash Point: 337.3°C
• Appearance: /
• Density: 1.52g/cm³
• Vapor Pressure: 6.03E-17mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: 1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid(114610-10-5)
• EPA Substance Registry System: 1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)cinnoline-3-carboxylic acid(114610-10-5)

Safety Data

• Hazardous Substances Data: 114610-10-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H16F2N4O3/c20-11-1-3-12(4-2-11)25-15-10-16(24-7-5-22-6-8-24)14(21)9-13(15)18(26)17(23-25)19(27)28/h1-4,9-10,22H,5-8H2,(H,27,28)

Upstream product

• 371-40-4 4-fluoroaniline 
• 114610-30-9 ethyl 2,4-dichloro-5-fluoro-α-(4-fluorophenylhydrazono)benzoylacetate 
• 114610-31-0 ethyl 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate 
• 129527-48-6 methyl 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylate 
• 129527-44-2 methyl 2,4-dichloro-5-fluoro-α-(4-fluorophenylhydrazono)benzoylacetate 
• 86483-51-4 ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate 
• 103319-17-1 methyl 2,4-dichloro-5-fluoro-benzoylacetate 
• 111760-50-0 2,4-dichloro-5-fluorobenzoylacetic acid 
• 704-10-9 2,4-dichloro-5-fluoroacetophenone 
• 110-85-0 piperazine 
• 114610-09-2 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxocinnoline-3-carboxylic acid 

Relevant articles and documents

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOCINNOLINE-3-CARBOXYLIC ACIDS

The coupling reaction of corresponding benzene diazonium chlorides with benzoyl acetates IIIa-IIIc yielded intermediates IVa-IVe.Their intermolecular nucleophilic cyclization provided 1-aryl-1,4-dihydro-4-oxocinnoline-3-carboxylates Va-Ve.Compounds Va, Vb, Vd, and Ve were hydrolyzed to acids VIa-VIc.Treatment of these acids with the respective cyclic amines yielded compounds VIIa-VIIg which were converted to their hydrochlorides.All compounds prepared were tested for their antimicrobial activity in vitro.