127106-65-4Relevant academic research and scientific papers
Synthesis and initial pharmacology of dual-targeting ligands for putative complexes of integrin αvβ3 and PAR2
Dockendorff, Chris,Gandhi, Disha M.,Hernandez, Irene,Holyst, Trudy,Majewski, Mark W.,Rosas, Ricardo,Wang, Zhengli,Weiler, Hartmut,Zhu, Jieqing
, p. 940 - 949 (2020/09/21)
Unpublished data from our labs led us to hypothesize that activated protein C (aPC) may initiate an anti-inflammatory signal in endothelial cells by modulating both the integrin αVβ3 and protease-activated receptor 2 (PAR2), which may exist in close proxi
α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors
Cui, Peng,McCalmont, William F.,Tomsig, Jose L.,Lynch, Kevin R.,Macdonald, Timothy L.
, p. 2212 - 2225 (2008/09/21)
Autotaxin (ATX) is an attractive pharmacological target due to its lysophospholipase D activity which leads to the production of lysophosphatidic acid (LPA). Blockage of ATX produced LPA by small molecules could be a potential anticancer chemotherapy. In our previous study, we have identified the two β-hydroxy phosphonate analogs of LPA (compounds f17 and f18) as ATX inhibitors. With this work, we investigated α- and β-substituted phosphonate analogs of LPA and evaluated them for ATX inhibitory activity. The stereochemistry of β-hydroxy phosphonates was also studied.
