1147334-99-3Relevant academic research and scientific papers
A class of 1, 2, 5 - oxadiazole - 2 oxide analogs, its preparation and use
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, (2017/04/21)
The invention provides 1,2,5-oxadiazole-2 oxide analogue with a structure shown as general formula I, and a preparation method and an application thereof. The 1,2,5-oxadiazole-2 oxide analogue has the activity for resisting schistosome thioredoxin glutathione reductase, kills schistosome by blocking a normal redox equilibrium physiological metabolism process of schistosome cells, can be used as a drug lead for development of drugs for treating schistosomiasis, and provides novel means for preventing and treating schistosomiasis. The general formula I is shown in the description.
An expedient synthesis of new 2-(furoxan-3-yl)thiazolidin-4-one derivatives
Kumar, Singam Naveen,Kumar, Chebolu Naga Sesha Sai Pavan,Anudeep, Sri Ranga Vanarasi,Sharma, Kirti Kumari,Rao, Vaidya Jayathirtha,Babu, Nanubolu Jagadeesh
, p. 32 - 49 (2016/10/30)
A series of new biologically interesting furoxan-3-thiazolidinones have been synthesized via one-pot three-component reaction of furoxan aldehydes, anilines and mercaptoacetic acid. The multi-component reaction involves condensation of furoxan aldehyde with aniline to give imine; the formed imine undergoes nucleophilic addition with mercaptoacetic acid, followed by cyclisation with loss of H2O to obtain the desired products. All the synthesized compounds were well characterized using spectral techniques and confirmed by an X-ray crystal structure for one compound.
Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents
Rai, Ganesha,Thomas, Craig J.,Leister, William,Maloney, David J.
supporting information; experimental part, p. 1710 - 1713 (2009/07/05)
The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.
