114748-67-3

Usage

Uses

Used in Antiviral Applications:
7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as an antiviral agent for its potential activity against herpes simplex virus and human immunodeficiency virus (HIV). It functions by inhibiting the synthesis of viral DNA, thereby preventing viral replication and reducing the spread of the virus in the body.
Used in Cancer Therapy:
7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as a potential therapeutic agent in cancer treatment. Its unique structure and properties are being investigated for their potential to target and inhibit the growth of cancer cells, offering a new avenue for cancer therapy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as a research compound for the development of new antiviral and anticancer drugs. Its distinct structure and potential therapeutic properties make it a valuable candidate for further investigation and potential incorporation into novel therapeutic agents.
Used in Biomedical Research:
7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as a research tool in biomedical research to study the mechanisms of viral replication and cancer cell growth. Its unique properties allow researchers to gain insights into the molecular processes involved in these diseases, potentially leading to the discovery of new targets for treatment and the development of more effective therapies.

Upstream product

• 114748-66-2 2-Amino-5-iodo-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 98891-39-5 7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin 
• 114748-63-9 4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 114748-62-8 (2R,3S,5R)-5-(4-Methoxy-2-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-trityloxymethyl-tetrahydro-furan-3-ol 
• 114748-65-1 5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 114748-64-0 5-Iodo-4-methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 29877-76-7 4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine 
• 115920-25-7 Thiocarbonic acid O-[(2R,3S,5R)-5-(4-methoxy-2-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 115899-60-0 5-Iodo-2-methanesulfinyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 

Downstream Products

• 114748-68-4 N-{3-[2-Amino-7-((S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide 
• 114748-68-4 N-{3-[2-Amino-4-hydroxy-7-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide 
• 114748-68-4 N-{3-[2-Amino-7-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF 7-IODO-2',3'-DIDEOXY-7-DEAZAPURINE NUCLEOSIDES, KEY INTERMEDIATES IN THE PREPARATION OF REAGENTS FOR THE AUTOMATED SEQUENCING OF DNA

Practical synthesis of 7-iodo-2',3'-dideoxy-7-deazaadenosine and 7-iodo-2',3'-dideoxy-7-deazaguanosine are described.These iodonucleosides can be converted into fluorescence-tagged chain-terminating substrates for DNA polymerases.