114748-67-3

Basic information

• Product Name: 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine
• Synonyms: 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine;7-I-7-Deaza-ddG;2-Amino-3,7-dihydro-5-iodo-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-4H-pyrrolo[2,3-d]pyrimidin-4-one;7-Iodo-2',3'-Dideoxy-7-Deaza-D-Guanosine;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro-5-iodo-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-7-Deaza-2'3'-dideoxy-7-iodoguanosine
• CAS NO: 114748-67-3
• Molecular Formula: C11H13IN4O3
• Molecular Weight: 376.15
• EINECS: -0
• Mol File: 114748-67-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 2.35±0.1 g/cm3(Predicted)
• PKA: 10.28±0.20(Predicted)
• CAS DataBase Reference: 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine(114748-67-3)
• EPA Substance Registry System: 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine(114748-67-3)

Safety Data

• Hazardous Substances Data: 114748-67-3(Hazardous Substances Data)

Usage

Description

7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is a chemical compound with the molecular formula C10H12IN5O3. It is a modified nucleoside analog of guanosine, featuring a deaza or deoxyriboside sugar moiety and an iodo substituent at the 7 position. 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine has been studied for its potential antiviral activity, particularly against herpes simplex virus and human immunodeficiency virus (HIV), and is believed to inhibit viral replication by interfering with the synthesis of viral DNA. Additionally, due to its unique structure, 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is also being investigated for its potential use in cancer therapy. Overall, this chemical compound shows promise for various therapeutic applications due to its distinct structure and potential antiviral and anticancer properties.

Uses

Used in Antiviral Applications:
7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as an antiviral agent for its potential activity against herpes simplex virus and human immunodeficiency virus (HIV). It functions by inhibiting the synthesis of viral DNA, thereby preventing viral replication and reducing the spread of the virus in the body.
Used in Cancer Therapy:
7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as a potential therapeutic agent in cancer treatment. Its unique structure and properties are being investigated for their potential to target and inhibit the growth of cancer cells, offering a new avenue for cancer therapy.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as a research compound for the development of new antiviral and anticancer drugs. Its distinct structure and potential therapeutic properties make it a valuable candidate for further investigation and potential incorporation into novel therapeutic agents.
Used in Biomedical Research:
7-Iodo-2',3'-Dideoxy-7-Deaza-Guanosine is used as a research tool in biomedical research to study the mechanisms of viral replication and cancer cell growth. Its unique properties allow researchers to gain insights into the molecular processes involved in these diseases, potentially leading to the discovery of new targets for treatment and the development of more effective therapies.

Upstream product

• 115920-25-7 Thiocarbonic acid O-[(2R,3S,5R)-5-(4-methoxy-2-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 115899-60-0 5-Iodo-2-methanesulfinyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 29877-76-7 4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 114748-66-2 2-Amino-5-iodo-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 114748-64-0 5-Iodo-4-methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 114748-65-1 5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 114748-62-8 (2R,3S,5R)-5-(4-Methoxy-2-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-trityloxymethyl-tetrahydro-furan-3-ol 
• 114748-63-9 4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 98891-39-5 7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin 

Downstream Products

• 114748-68-4 N-{3-[2-Amino-7-((S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide 
• 114748-68-4 N-{3-[2-Amino-4-hydroxy-7-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide 
• 114748-68-4 N-{3-[2-Amino-7-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl]-prop-2-ynyl}-2,2,2-trifluoro-acetamide 

Relevant articles and documents

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