114748-68-4

Usage

Uses

Used in Pharmaceutical Research and Development:
7-TFA-ap-7-Deaza-ddG is utilized as a research tool for probing the structure and function of nucleic acids. Its unique properties allow scientists to gain insights into the fundamental mechanisms of nucleic acid interactions and to explore its potential as a therapeutic agent.
Used in Cancer Treatment:
In the field of oncology, 7-TFA-ap-7-Deaza-ddG is considered for its potential use as an anticancer agent. Its unique structure may offer new avenues for the development of targeted therapies against various types of cancer, potentially leading to more effective treatments with fewer side effects.
Used in Antiviral Therapy:
7-TFA-ap-7-Deaza-ddG is also being explored for its potential in antiviral therapy. Its ability to interact with nucleic acids could be leveraged to develop new antiviral drugs that target specific viral mechanisms, offering a novel approach to treating viral infections.
Used in Drug Design and Synthesis:
In the pharmaceutical industry, 7-TFA-ap-7-Deaza-ddG serves as a key component in the design and synthesis of new drugs. Its unique chemical properties make it a valuable building block for the creation of innovative pharmaceutical compounds with potential applications in various therapeutic areas.
Used in Diagnostics:
7-TFA-ap-7-Deaza-ddG may also find applications in the development of diagnostic tools. Its interaction with nucleic acids could be harnessed to create sensitive and specific diagnostic assays for detecting diseases at an early stage, improving patient outcomes through early intervention.

Upstream product

• 14719-21-2 trifluoroacetyl-propargyl amine 
• 114748-67-3 7-iodo-2',3'-dideoxy-7-deazaguanosine 
• 114748-63-9 4-Methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 29877-76-7 4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine 
• 114748-67-3 2-Amino-7-((2R,5S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-ol 
• 114748-67-3 2-Amino-7-((S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-iodo-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 115920-25-7 Thiocarbonic acid O-[(2R,3S,5R)-5-(4-methoxy-2-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 115899-60-0 5-Iodo-2-methanesulfinyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 114748-64-0 5-Iodo-4-methoxy-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine 
• 114748-65-1 5-Iodo-2-methylsulfanyl-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 114748-62-8 (2R,3S,5R)-5-(4-Methoxy-2-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-2-trityloxymethyl-tetrahydro-furan-3-ol 
• 114748-66-2 2-Amino-5-iodo-7-((2R,5S)-5-trityloxymethyl-tetrahydro-furan-2-yl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 98891-39-5 7-(2'-Desoxy-β-D-erythro-pentofuranosyl)-4-methoxy-2-methylthio-7H-pyrrolo<2,3-d>pyrimidin 

Relevant academic research and scientific papers

Solvent, not palladium oxidation state, is the primary determinant for successful coupling of terminal alkynes with iodo-nucleosides

Coupling of iodo-nucleosides with terminal alkynes such as 3-(acylamino)propynes, whose initial products readily undergo secondary cyclization reactions, can be effected smoothly by the standard catalysis with (Ph3P)2PdCl2

Palladium-Catalyzed Synthesis of Alkynylamino Nucleosides. A Universal Linker for Nucleic Acid

A method for attaching alkynylamino "linkers" to nucleosides and nucleotides is described.Protected or unprotected alkynylamines are coupled to iodonucleosides in dimethylformamide using a 1:2 mol ratio of tetrakis(triphenylphosphine)palladium(0) and copper(I) iodide, a catalyst system superior to the standard system using palladium(II) species.The resulting alkynylamino nucleosides are useful for enzymatic or chemical labeling of all four bases of DNA.