114772-62-2

Basic information

• Product Name: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-iodo-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol-1- yl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 114772-62-2
• Molecular Formula: C30H39IN2O5
• Molecular Weight: 634.555
• Mol File: 114772-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-iodo-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol-1- yl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-iodo-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol-1- yl]methyl]-, 1,1-dimethylethyl ester(114772-62-2)
• EPA Substance Registry System: [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-4-iodo-5-[[(2-methoxyethoxy)methoxy]methyl]-1H-imidazol-1- yl]methyl]-, 1,1-dimethylethyl ester(114772-62-2)

Safety Data

• Hazardous Substances Data: 114772-62-2(Hazardous Substances Data)

Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 
• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 84392-32-5 4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole 
• 114772-36-0 tert-butyl 4'-methyl-2-biphenylcarboxylate 
• 74201-13-1 N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide 
• 133379-10-9 2-n-butyl-5-hydroxymethyl-4-iodoimidazole 
• 68283-19-2 2-butyl-5-hydroxymethyl-1H-imidazole 
• 114772-35-9 4'-methylbiphenyl-2-carboxylic acid chloride 
• 7148-03-0 o-tolylbenzoic acid 
• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 114772-46-2 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-(hydroxymethyl)-4-iodoimidazole 

Downstream Products

• 114798-96-8 2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole 

Relevant articles and documents

Nonpeptide Angiotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl)imidazoles as Potent, Orally Active Antihypertensives

A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared.These N-(biphenylylmethyl)imidazoles, e.g. 2-butyl-1--4-chloro-5-(hydroxymethyl)imidazole, differ from the previously reported N-(benzamidobenzyl)imidazoles and related compounds in that they produce a potent antihypertensive effect upon oral administration; the earlier series generally were active only when administered intravenously.It has been found that the acidic group at the 2'-position of the biphenyl is essential.Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency.The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring has been found to be the most effective.The tetrazole derivative, DuP 753, is currently in development for the treatment of hypertension.