84392-32-5

Basic information

• Product Name: 4,4-DIMETHYL-2-(4'-METHYL-2-BIPHENYLYL)-2-OXAZOLINE
• Synonyms: 4,4-DIMETHYL-2-(4'-METHYL-2-BIPHENYLYL)-2-OXAZOLINE;4,4-dimethyl-2-(4'-methyl-2-biphenylyl)-2-oxazoli;DMT-dT-CPG column
• CAS NO: 84392-32-5
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.35
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Oxazolines/Oxazolidines
• Mol File: 84392-32-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 45-48 °C(lit.)
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,4-DIMETHYL-2-(4'-METHYL-2-BIPHENYLYL)-2-OXAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIMETHYL-2-(4'-METHYL-2-BIPHENYLYL)-2-OXAZOLINE(84392-32-5)
• EPA Substance Registry System: 4,4-DIMETHYL-2-(4'-METHYL-2-BIPHENYLYL)-2-OXAZOLINE(84392-32-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 84392-32-5(Hazardous Substances Data)

Upstream product

• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 66464-20-8 2-(2-fluorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 2417-95-0 p-tolyllithium 
• 98191-99-2 2-(2-chlorophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 74201-13-1 N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide 
• 579-75-9 2-Methoxybenzoic acid 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 106-38-7 para-bromotoluene 
• 5720-05-8 4-methylphenylboronic acid 
• 32664-13-4 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 

Downstream Products

• 7148-03-0 o-tolylbenzoic acid 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 16191-28-9 2-(4-methylphenyl)benzaldehyde 
• 114772-78-0 (4′-methyl-[1,1′-biphenyl]-2-yl)methanol 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 114772-36-0 tert-butyl 4'-methyl-2-biphenylcarboxylate 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 114772-40-6 4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester 
• 133910-06-2 2-<2-fluoro-2-(benzenesulfonyl)ethen-1-yl>-4'-methylbiphenyl 
• 124750-63-6 2-(4'-methylbiphenyl-2-yl)-1-(benzenesulfonyl)acrylonitrile 
• 133910-05-1 2-<2-fluoro-1-hydroxy-2-(benzenesulfonyl)ethyl>-4'-methylbiphenyl 
• 114799-00-7 2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-5-(hydroxymethyl)imidazole 
• 114772-46-2 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-(hydroxymethyl)-4-iodoimidazole 

Relevant articles and documents

Convenient synthesis of pharmacologically active ortho-substituted biaryl oxazolines via the suzuki reaction

We describe an efficient protocol for the Suzuki-Miyaura synthesis of ortho-substituted biphenyl oxazolines from 2-(2-bromophenyl)-4,4-dimethyl-2- oxazoline and aryl boronic acids or aryl boronates. The Suzuki coupling is carried out in the presence of Pd

Synthesis, characterization and biological evaluation of benzimidazole and benzindazole derivatives as anti-hypertensive agents

A substituted benzimidazole and benzindazole derivatives had been synthesized having antihypertensive activity through antagonizing the angiotensin II (Ang II) receptors. The in vivo antihypertensive activity of the compounds was done with acute renal hypertension model. Two compounds TG 1 and TG 3 were found to have antihypertensive activity comparable to Telmisartan which is a prototype for Angiotensin II receptor antagonists class of drugs.In an antihypertensive study the compounds TG 1, TG 2 and TG 3 had systolic blood pressures of 147.2 mm/Hg, 168.2 mm/Hg, and 126.3 mm/Hg, respectively. This systolic blood pressure was lower than the disease control vehicle-treated rodents, which had a systolic blood pressure of 167.2 mm/Hg. The diastolic blood pressure was 119.7 mm/Hg, 124.7 mm/Hg and 88.83 mm/Hg, respectively and that of the disease control vehicle-treated rodents was 122.3 mm/Hg. TG 3 had comparable decrease in the MABP to Telmisartan. These encouraging results make compound TG 3 effective anti-hypertensive drug candidate and worthy of further investigation.

Process for the preparation of imidazopyridine derivatives, and intermediates therefore

The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: STR1 The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo-[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous.Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the industrial production.