783357-48-2

Upstream product

• 6148-64-7 ethyl potassium malonate 
• 114776-15-7 2-chloro-4-fluoro-5-nitrobenzoic acid 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 120890-66-6 2-chloro-4-fluoro-5-nitrobenzoyl chloride 

Downstream Products

• 783357-49-3 3-(4-tert-butylamino-2-chloro-5-nitrophenyl)-3-oxopropionic acid ethyl ester 
• 783357-60-8 1-(2,4-difluoro-phenyl)-7-(2,4-difluoro-phenylamino)-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 783357-59-5 1-cyclohexyl-7-cyclohexylamino-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 783357-65-3 3-(2-chloro-5-nitro-4-thiomorpholin-4-yl-phenyl)-3-oxo-propionic acid ethyl ester 
• 783357-64-2 3-(2-chloro-4-morpholin-4-yl-5-nitro-phenyl)-3-oxo-propionic acid ethyl ester 
• 783357-63-1 3-(2-chloro-4-cyclopropylamino-5-nitro-phenyl)-3-oxo-propionic acid ethyl ester 

Relevant academic research and scientific papers

NOVEL COMPOSITIONS AND METHODS OF USE

Described herein are novel enzyme inhibitors. In some embodiments the enzyme inhibitors are integrase inhibitors, particularly HIV integrase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV integrase as a method of treating or preventing HIV, AIDS or related disorders.

New 6-nitroquinolones: Synthesis and antimicrobial activities

Pursuing our searches on quinolonecarboxylic acids we used a simple three-step one pot procedure to synthesize novel 1,7-disubstituted-6- nitroquinolones. The new derivatives were tested against Mycobacterium tuberculosis and Mycobacterium avium complex (