114804-76-1Relevant articles and documents
Multichromophoric cyclodextrins. 4. Light conversion by antenna effect
Jullien, Ludovic,Canceill, Josette,Valeur, Bernard,Bardez, Elisabeth,Lefèvre, Jean-Pierre,Lehn, Jean-Marie,Marchi-Artzner, Valérie,Pansu, Robert
, p. 5432 - 5442 (1996)
A water soluble β-cyclodextrin (CD-NA) bearing seven naphthoyl chromophores forms very stable 1:1 complexes with a merocyanine laser dye DCM-OH (4-(dicyanomethylene)-2-methyl-6-(p-(bis(hydroxyethyl)amino)-styryl)-4 H-pyran). The antenna effect, i.e. energ
Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors
Deberardinis, Albert M.,Madden, Daniel J.,Banerjee, Upasana,Sail, Vibhavari,Raccuia, Daniel S.,De Carlo, Daniel,Lemieux, Steven M.,Meares, Adam,Hadden, M. Kyle
, p. 3724 - 3736 (2014/05/20)
A structure-activity relationship study for a series of vitamin D3-based (VD3) analogues that incorporate aromatic A-ring mimics with varying functionality has provided key insight into scaffold features that result in potent, selective Hedgehog (Hh) pathway inhibition. Three analogue subclasses containing (1) a single substitution at the ortho or para position of the aromatic A-ring, (2) a heteroaryl or biaryl moiety, or (3) multiple substituents on the aromatic A-ring were prepared and evaluated. Aromatic A-ring mimics incorporating either single or multiple hydrophilic moieties on a six-membered ring inhibited the Hh pathway in both Hh-dependent mouse embryonic fibroblasts and cultured cancer cells (IC50 values 0.74-10 μM). Preliminary studies were conducted to probe the cellular mechanisms through which VD3 and 5, the most active analogue, inhibit Hh signaling. These studies suggested that the anti-Hh activity of VD3 is primarily attributed to the vitamin D receptor, whereas 5 affects Hh inhibition through a separate mechanism.
VITAMIN D RECEPTOR MODULATORS
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Page/Page column 26, (2008/06/13)
The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, ZP, LP1, LP2 LNP, RP3, RN, and ZNP are defined herein, their prepa
NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 46, (2010/02/11)
The present invention relates to novel compounds of formula (I) and their pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.
Optically active naphthalene compounds and liquid crystal materials and devices incorporating them
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, (2008/06/13)
Optically active naphthalene compounds having the formula: STR1 in which X and Y are selected from combinations (a), (b) and (c): (a) X is C1-10 alkyl or alkoxy and Y is C4-16 optically active alkyl, (b) X is C1-10 alkyl o