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  • High quality 6-hydroxy-2-naphthalene carboxylic acid;2-hydroxy-6-naphthoic acid supplier in China

    Cas No: 16712-64-4

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  • Simagchem Corporation
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16712-64-4 Usage


6-Hydroxy-2-naphthoic acid is a hydroxynaphthoic acid derivative, characterized by its pale brown powder appearance. It is known for its ability to form co-crystals with caffeine and is synthesized using whole cells of the recombinant Escherichia coli strain expressing CYP199A2, which catalyzes the regioselective oxidation of 6-hydroxy-2-naphthoic acid to produce 6,7-dihydroxynaphthoic acid.


Used in Engineering Plastics:
6-Hydroxy-2-naphthoic acid is used as a monomer for the production of engineering plastics, contributing to their heat-resistant properties and enhancing their overall performance.
Used in Organic Pigments:
6-Hydroxy-2-naphthoic acid serves as a key component in the synthesis of organic pigments, providing color and stability to various products.
Used in Liquid Crystal Materials:
6-Hydroxy-2-naphthoic acid is utilized in the creation of liquid crystal materials, which are essential in the manufacturing of displays and other optical applications.
Used in Medicine:
The compound finds application in the pharmaceutical industry, potentially for the development of new drugs and therapeutic agents.
Used in Heat-Resistant Materials:
As a monomer, 6-Hydroxy-2-naphthoic acid is crucial in the development of materials with high heat resistance, suitable for various industrial applications.
Used in Synthesis of 5-Bromo-6-Hydroxy-2-Naphthoic Acid:
6-Hydroxy-2-naphthoic acid is used as a starting material in the synthesis of 5-bromo-6-hydroxy-2-naphthoic acid, which has its own set of applications.
Used in Liquid-Crystalline Epoxy Resins:
The compound is also employed in the production of liquid-crystalline epoxy resins, which are valuable in the coatings and adhesives industry due to their unique properties.

Flammability and Explosibility


Check Digit Verification of cas no

The CAS Registry Mumber 16712-64-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,1 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 16712-64:
104 % 10 = 4
So 16712-64-4 is a valid CAS Registry Number.

16712-64-4 Well-known Company Product Price

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  • Alfa Aesar

  • (B21791)  6-Hydroxy-2-naphthoic acid, 99%   

  • 16712-64-4

  • 1g

  • 287.0CNY

  • Detail
  • Alfa Aesar

  • (B21791)  6-Hydroxy-2-naphthoic acid, 99%   

  • 16712-64-4

  • 5g

  • 588.0CNY

  • Detail
  • Alfa Aesar

  • (B21791)  6-Hydroxy-2-naphthoic acid, 99%   

  • 16712-64-4

  • 25g

  • 2457.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 6-Hydroxy-2-naphthoic acid

1.2 Other means of identification

Product number -
Other names 6-Hydroxy-2-naphthoic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16712-64-4 SDS

16712-64-4Related news

Polar packing structure in copolyester comprising 4-hydroxy benzoic acid and 6-Hydroxy-2-naphthoic acid (cas 16712-64-4) as studied by high resolution solid state 13C NMR spectroscopy and quantum chemistry09/08/2019

The copolyester comprising 73 mol% of 4-hydroxy benzoic acid and 27 mol% of 6-hydroxy-2-naphthoic acid, so called Vectra, was known to show the strong second harmonic generation (SHG) when it has a high molecular weight. Using high-resolution solid state 13C NMR, we investigated the intermolecul...detailed

16712-64-4Relevant articles and documents



, p. 8,14 (1951)


Effects of alkali and alkaline earth metals on the Kolbe-Schmitt reaction

Rahim, Mohammad Abdur,Matsui, Yoshihisa,Kosugi, Yoshio

, p. 619 - 622 (2002)

It was found that the carboxylations of magnesium, calcium, and barium phenoxides with carbon dioxide at 260 °C produced salicylic acid and dicarboxylic acids (4-hydroxyisophthalic acid and 2-hydroxyisophthalic acid) in very high yields (80-100%), exceeding that of the ordinary Kolbe-Schmitt reaction. The orientation (ortho/para ratio) was controlled not only by chelations of the intermediate with alkaline earth metal (Mg, Ca, Ba) ions, resulting in salicylic acid, but also by the sizes of metal ions (Rb, Cs), giving p-hydroxybenzoic acid in a much higher ratio than the widely used method with potassium or sodium phenoxide. These alkaline earth metals worked to produce 3-hydroxy-2-naphthoic acid by the reaction of 2-naphthoxide with carbon dioxide, but the yield of 6-hydroxy-2-naphthoic acid was comparable to that of 3-hydroxy-2-naphthoic acid when cesium or rubidium 2 naphthoxide was employed. Considerably high yields (~60%) of 6-hydroxy-2-naphthoic acid, a monomer of one of the best liquid-crystal polymers, was attained by the carboxylation of cesium or rubidium 2-naphthoxide in the presence of potassium or sodium carbonate, where the alkali metal ion was supposed to increase the reactivity of the substrate. The formation of "binol" was observed in the preparation of 2-naphthoxides with metal hydroxides, especially with copper(II) ion.

Synthesis and cytotoxicity of n-substituted dibenzo[a,j]xanthene-3,11-dicarboxamide derivatives

Song, Yongbin,Yang, Yihui,Wu, Lijun,Dong, Naiwei,Gao, Shang,Ji, Hongrui,Du, Xia,Liu, Bo,Chen, Guoyou,Dembinski, Roman

, (2017/04/03)

In order to study the structure-activity relationships of xanthene derivatives, four series of N-substituted 14-aryl-14H-dibenzo[a,j]xanthene-3,11-dicarboxamide derivatives were synthesized. The structures of all compounds were identified by 1H-NMR HR-MS and IR spectra in which compounds 6a-h were further identified by 13C-NMR spectra. The in vitro antitumor activity of the synthesized compounds was tested by MTT assay. Most of them displayed strong inhibitory activity on human hepatocellular carcinoma cell lines (SK-HEP-1 HepG2 and SMMC-7721 cells) and acute promyelocytic leukemia NB4 cells. Compounds 6c-6e exhibited significant inhibitory activity against NB4 cells with IC50 values of 0.52 μM and 0.76 μM respectively much lower than 5.31 μM of the positive control As2O3.

Production of aromatic hydroxycarboxylic acid


Paragraph 0065-0067; 0069-0070; 0071-0072, (2018/05/17)

PROBLEM TO BE SOLVED: To provide a production method capable of obtaining aromatic hydroxycarboxylic acid at high yield even under a reaction condition at low temperature. SOLUTION: The method for production of aromatic hydroxycarboxylic acid includes a process of reacting an alkali metal salt of aromatic hydroxy compounds with carbon dioxide in a medium. The method is characterized by performing the above reaction in the presence of a ligand alone or as its metal complex of 0.01-1.0 mol based on 1 mol of the alkali metal salt of the aromatic hydroxy compound. COPYRIGHT: (C)2012,JPOandINPIT

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