114863-86-4Relevant academic research and scientific papers
Multiple Aryne Insertions into Oxindoles: Synthesis of Bioactive 3,3-Diarylated Oxindoles and Dibenzo[b,e]azepin-6-ones
Samineni, Ramesh,Bandi, Chandramohan Reddy C.,Srihari, Pabbaraja,Mehta, Goverdhan
, p. 6184 - 6187 (2016)
An aryne insertion cascade reaction on oxindoles has been observed and constitutes a convenient one pot preparation of bioactive di- and triarylated oxindoles in good yields under mild conditions. A temperature controlled reaction switch enables ready access to dibenzo[b,e]azepin-6-one derivatives employing the same reaction regime. This tactic has been extended to a short synthesis of potent antiulcer agent darenzepine.
