114937-06-3Relevant academic research and scientific papers
Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid
-
, (2008/06/13)
Compounds of formula STR1 in which R, R1 and Y have the meanings shown in the description, their preparation by condensing an aldehyde or a ketone with cysteine or a derivative thereof and their use in the pharmaceutical field. The compounds of
Synthesis and in solution behaviour of new 2-substituted-4-thiazolidinecarboxylic acid derivatives
Chiarino,Ferrario,Pellacini,Sala
, p. 589 - 593 (2007/10/02)
A number of 2-substituted-4-thiazolidinecarboxylic acid derivatives were synthesized by cyclocondensation of L-cysteine or its esters with various aldehydes, resulting from acids provided with antiinflammatory properties. In the cyclocondensation a new chiral center at C-2 position of thiazolidine ring is formed giving rise to a mixture of diastereoisomers which can be partially separated. These diastereoisomers show in solution a fast epimerisation at the same chiral center as evidenced by 1H-nmr studies.
Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid
-
, (2008/06/13)
Compounds of formula in which R, R1 and Y have the meanings shown in the description, their preparation by condensing an aldehyde or a ketone with cysteine or a derivative thereof and their use in the pharmaceutical field. The compounds of formula I possess antipyretic, anti--inflammatory, mucolytic and analgesic activity together with a low capacity to cause gastric injuries. The compounds of formula I, furthermore, are particularly useful in the treatment of ischemia and reperfusion syndromes.
