115015-34-4Relevant academic research and scientific papers
Metalation of Hantzsch Esters and Mixed Amide Esters: A General Route to C-2 Functionalized 1,4-Dihydropyridines
Poindexter, Graham S.,Licause, Joseph F.,Dolan, Peter L.,Foley, Michael A.,Combs, Charles M.
, p. 3811 - 3820 (2007/10/02)
1,4-Dihydropyridine (Hantzsch) diesters 3a-e readily undergo metalation at the C-2 methyl (vinylogous ester) position on treatment with alkyllithium bases.The resulting anion intermediates can be treated with electrophilic reagents to afford 1,4-dihydropy
METALATION OF 1,4-DIHYDROPYRIDINE ESTERS
Poindexter, Graham S.,Foley, Michael A.,Licause, Joseph F.
, p. 3393 - 3396 (2007/10/02)
4-Aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic esters are metalated at the NH and the C-2 methyl positions via treatment with two equivalents of n-butyl lithium.The resulting dilithio species can be treated with a variety of electrophiles to fur
2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers
Taylor,Badger,Steffen,Haleen,Pugsley,Shih,Weishaar
, p. 1659 - 1664 (2007/10/02)
The title compounds are novel double bond isomers of 1,4-dihydropyridine-type calcium channel blockers (CCB). These derivatives were prepared by using the Hantzsch dihydropyridine synthesis. The assignment of structure was based on spectroscopic data and
