115091-84-4Relevant academic research and scientific papers
The synthesis and antifungal activity of 2-amino-4-aryl-4H,5H-benzothiopyranopyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-benzothiopyranopyridine-3-carbonitriles
Nakib, T.A.,Bezjak, V.,Rashid, S.,Fullam, B.,Meegan, M.J.
, p. 221 - 230 (2007/10/02)
This paper describes the synthesis of a series of 2-amino-4-aryl-4H,5H-benzothiopyranopyran-3-carbonitriles and 2-alkoxy-4-aryl-5H-benzothiopyranopyridine-3-carbonitriles.All of these products were studied for antifungal activity and many of these compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata, and Trichosporon cutaneum.
A NOVEL SYNTHETIC ROUTE TO PHENYL-SUBSTITUTED PYRIDINES; SYNTHESIS OF BENZOPYRANOPYRIDINES, BENZOTHIOPYRANOPYRIDINES AND PYRIDOBENZOTHIAZINES(1-AZAPHENOTHIAZINES)
Tyndall, D. V.,Al Nakib, T.,Meegan, M. J.
, p. 2703 - 2706 (2007/10/02)
Reaction of 1,3-diphenylpropenone with malononitrile in base affords 1,4-diphenyl-2-methoxypyridine-3-carbonitrile.This reaction has been applied to a general synthesis of phenyl-substituted benzopyranopyridines, benzothiopyranopyridines and pyridobenzothiazines(1-azaphenothiazines).
