115127-16-7

Basic information

• Product Name: 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-dione
• Synonyms: 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-dione;1,9-dihydropyrimido[6,5-b]indole-2,4-dione;1,9-dihydropyrimido[6,5-b]indole-2,4-quinone;9H-Pyrimido[4,5-b]indole-2,4-diol;AIDS148469;AIDS-148469;NCI60_028828;NSC680815
• CAS NO: 115127-16-7
• Molecular Formula: C10H7N3O2
• Molecular Weight: 201.18148
• Mol File: 115127-16-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-dione(115127-16-7)
• EPA Substance Registry System: 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-dione(115127-16-7)

Safety Data

• Hazardous Substances Data: 115127-16-7(Hazardous Substances Data)

Usage

Chemical class

pyrimidoindoles

Natural occurrence

found in various plants and foods, as well as in tobacco smoke

Biological activities

antioxidant, anti-inflammatory, and anticancer properties

Neuroprotective effects

potential role in promoting neuroprotection

Neurotransmitter modulation

ability to modulate the activity of neurotransmitters in the brain

Therapeutic applications

potential use in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.

Upstream product

• 124-38-9 carbon dioxide 
• 115127-14-5 6-azido-1,3-dibenzyl-5-phenyl-pyrimidine-2,4(1H,3H)-dione 
• 115127-12-3 1,3-dibenzyl-5-phenyl-pyrimidine-2,4-6(1H,3H,5H)-trione 
• 115127-13-4 1,3-dibenzyl-6-chloro-5-phenyl-pyrimidine-2,4(1H,3H)-dione 
• 83-13-6 diethyl 2-phenylmalonate 
• 2613-89-0 phenylmalonic acid 
• 115127-15-6 1,3-dibenzyl-1H-pyrimido<4,5-b>indole-2,4(3H,9H)-dione 

Relevant articles and documents

Preparation method of heterocyclicpyrimidinedione compound

The invention discloses a preparation method of a heterocyclicpyrimidinedione compound and relates to the technology of medicinal chemistry. The preparation method comprises the following steps: 1) mixing an o-amino formonitrile heterocyclic compound and a catalyst to form a mixture, wherein the catalyst is [HDBN][TFE]; 2) in a CO2 environment, heating the mixture and reacting; 3) when the temperature is reduced to room temperature, adjusting the pH value to neutrality, and extracting, separating and collecting the an organic phase; drying, filtering and then vaporizing; performing column chromatography separation to obtain the heterocyclicpyrimidinedione compound. The preparation method disclosed by the invention has the advantages of low cost, environmental friendliness, simple preparation process and wide application range of substrate.

9H pyrimido[4,5b]indole 2,4 diones. The acid catalyzed cyclization of 6-(phenylhydrazino)uracils

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