1149333-40-3

Usage

Uses

Used in Chemical Research:
Tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of chemical entities, making it a valuable component in the development of new molecules with specific properties.
Used in Pharmaceutical Research:
In the pharmaceutical industry, tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is used as an intermediate in the synthesis of potential drug candidates. Its incorporation into molecular structures can contribute to the development of new therapeutic agents, particularly those targeting specific biological pathways or receptors.
Used in Organic Synthesis:
As an intermediate in organic synthesis, tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is employed to construct complex organic molecules. Its reactivity and functional groups make it suitable for various synthetic routes, facilitating the formation of desired products in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
While the specific applications of tert-butyl 2-amino-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate are still under investigation, its role as a building block and intermediate in chemical and pharmaceutical research highlights its potential in contributing to the advancement of new chemical entities and therapeutic agents.

Upstream product

• 1346673-94-6 tert-butyl 2-[(diphenylmethylidene)amino]-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 
• 1013-88-3 Benzophenone imine 
• 1151665-15-4 2-chloro-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester 
• 1149333-39-0 tert-butyl 2-(trifluoromethanesulfonyloxy)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 
• 1036381-91-5 tert-butyl 2-hydroxy-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 
• 207691-65-4 N-tert-butoxycarbonyl-4-(tetrahydropyrrole-1-yl)-1,2,3,6-tetrahydropyridine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 210539-05-2 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 766545-20-4 2-chloro-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride 

Downstream Products

• 1149333-50-5 1.1-dimethylethyl 2-[({1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}carbonyl)amino]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 
• 1149333-53-8 1,1-dimethylethyl 2-[({1-[(3,4-dichlorophenyl)methyl]-1H-pyrazol-4-yl}carbonyl)amino]-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS

Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.

Inhibiting effect of trisubstituted pyrimidine derivative on protein kinase

The invention discloses a trisubstituted pyrimidine derivative with a structure shown as general formula (I), and pharmaceutically acceptable salt, ester or solvent compound thereof. The derivative isa protein kinase inhibitor, can be used individually or in combination with other drugs for cancer treatment, and has tremendous clinical application value. General formula (I) is shown as the specification.

CDK4/6 INHIBITORS AND USE THEREOF

The present disclosure relates to a compound of formula (I), or a pharmaceutically acceptable salt, a solvate, a stereoisomer, or tautomer thereof, a pharmaceutical composition comprising a compound of formula (A) or formula (B), and any subgenera thereof, and use of said compounds and compositions thereof, wherein R1, R2, R3a, R3b, R5, R6, X1, X2, Y and n are described herein.

PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound having an excellent CDK4/6 inhibiting activity. The present invention is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

Compound of CDK small-molecule inhibitor and application thereof

The invention relates to a novel compound used as a CDK small-molecule inhibitor and application thereof, and relates to a medicine composition comprising the compound, and application of the compound and the composition to treatment of diseases of excessive proliferative disorder. The formula of the compound is shown in the formula (I) (in the description). The new compound is a powerful cyclin-dependent kinases 4 (cdk4) inhibitor or a cyclin-dependent kinases 6 (cdk6) inhibitor.

PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

SUBSTITUTE 1, 6-NAPHTHYRIDINES FOR USE AS SCD INHIBITORS

The present invention relates to substituted tetrahydronaphthyridine (THN) compounds of the formula (I) and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for inhibiting SCD activity.