1152-57-4

Upstream product

• 105-53-3 diethyl malonate 
• 108-93-0 cyclohexanol 
• 504-64-3 carbon suboxide 
• 22096-22-6 sodium cyclohexanolate 
• 141-82-2 malonic acid 

Downstream Products

• 59735-16-9 2,2-Bis-(3,5-di-tert-butyl-4-hydroxy-benzyl)-malonic acid dicyclohexyl ester 
• 141590-84-3 2,4-Bis-cyclohexyloxycarbonyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentanedioic acid dicyclohexyl ester 
• 169615-01-4 dicyclohexyldiazomalonate 
• 1160974-84-4 biscyclohexyl 4-acetamidobenzalmalonate 
• 313229-95-7 cyclohexyl 2-oxo-2H-chromene-3-carboxylate 

Relevant academic research and scientific papers

Catalytic asymmetric conjugate allylation of coumarins

A catalytic asymmetric conjugate allylation was successfully developed to synthesize potential pharmacologically active 4-allyl-2-oxochroman skeletons. A dual activation strategy was employed by using N,N′-dioxide-Yb(OTf) 3 to activate coumarins and using (CuOTf)2?C 7H8 to activate tetraallyltin via transmetalation, respectively. Good yields and enantioselectivities were obtained under mild conditions.

S-TRIAZINE COMPOUNDS CONTAINING ONE AMINOSILOXANE GROUP AND TWO PARTICULAR PARA-AMINOBENZALMALONATE GROUPS; COSMETIC COMPOSITIONS CONTAINING SAID DERIVATIVES; USES OF SAID S-TRIAZINE DERIVATIVES

The invention concerns novel s-triazine compounds containing one aminosiloxane group and two particular para-aminobenzalmalonate groups. The invention also concerns cosmetic or dermatological compositions intended for the photoprotection of keratinous mat

Synthesis of caffeic acid esters

A new method for the preparation of caffeic acid esters was investigated. Ten caffeic acid esters were prepared by condensation of protocatechualdehyde with malonic acid mono-esters in moderate yield. Malonic acid mono-esters were prepared from the corresponding malonate di-esters. The conformations of compounds are trans (E) form.

One-Pot synthesis of 5-Alkylthio-3H-1,2-dithiole-3-thiones: Advantages and scopes

The reaction of dialkyl malonate esters with P2S5/S8 in boiling xylene in the presence of 2-mercaptobenzothiazole/ZnO as catalyst produces 5-alkylthio-3H-1,2-dithiole-3-thiones as major identifiable product. Moderate yields were obtained with malonate esters of primary alcohols. The reaction fails with malonate esters of secondary alcohols. Regarding the substituent in position two, dialkyl malonates with groups such as CH3, Ph, CH2Ph, OCH3 and Cl afford the corresponding 4-substituted derivatives whereas with Br and NO2 do not give the expected products. Some mechanistic evidences are described.

Pyrimidine derivatives

Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula STR1 wherein X is O or NR5, Y is O, S or NR5 wherein R5 is a hydrogen atom, a C1 -C6 alkyl group or the like; R1 and R2 may be the same or different and each is a hydrogen atom, a C1 -C6 alkyl group or the like; R3 is CN, or COOR6 wherein R6 is a C1 -C6 alkyl group, a C3 -C6 cycloalkyl group, an aryl group or the like; R4 is --SR7 or --NR8 R9 wherein R7 is a C1 -C6 alkyl group; R8 is a C1 -C6 alkyl group or the like; R9 is a hydrogen atom, a C1 -C6 alkyl group or the like, or R8 and R9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) STR2 wherein R10 represents a C1 -C6 alkyl group or the like or a pharmacologically acceptable salt thereof. The above-mentioned compounds are useful as a gastrointestinal prokinetic agent used for the therapy of digestive tract diseases.