1152473-72-7Relevant articles and documents
Identification of Thieno[3,2- d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3
Cho, Hanna,Choi, Hwan Geun,Jeon, Eunhye,Kim, Nam Doo,Kim, Sunghoon,Kim, Younghoon,Kwon, Nam Hoon,Lee, Jiwon,Moon, Youngji,Ryu, Seongshick,Shin, Injae,Sim, Taebo,Song, Chiman,Yoon, Hojong
, p. 11934 - 11957 (2021/08/20)
Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-d]pyrimidine derivatives. An intensive structure-activity relationship (SAR) study led