115306-77-9

Upstream product

• 13379-98-1 3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 156-87-6 propan-1-ol-3-amine 
• 115306-75-7 3-(tertbutyldimethylsiloxyl)propylamine 
• 115306-87-1 N-<3-(tert-butyldimethylsiloxy)propyl>phtalimide 

Downstream Products

• 115306-83-7 N-<3-(tert-butyldimethylsiloxy)propyl>-p-toluenesulfonate 
• 1111180-01-8 N-(3-(tert-butyldimethylsilyloxy)propyl)-N-(3-iodo-4-methylbenzyl)-4-methylbenzenesulfonamide 
• 1268631-17-9 C₂₆H₄₉NO₄SSi₂ 
• 1268630-81-4 C₁₄H₂₁NO₄S 
• 1296794-24-5 N-benzyl-3-((tert-butyldimethylsilyl)oxy)propan-1-amine 
• 1296794-23-4 N-benzyl-N-(3-((tert-butyldimethylsilyl)oxy)propyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Synthesis and unusual reactivity of N-tosyl-4,5-benzoazacyclodeca-2,6- diyne, yneamino-containing enediyne

Substitution of the propargylic carbon for nitrogen in cyclic 10-membered ring enediynes results in at least 2 orders of magnitude enhancement of reactivity. The mechanism of cycloaromatization of aza-enediynes, however, switches from radical (Bergman) to

Lewis Acid Catalyzed Electrophilic Aminomethyloxygenative Cyclization of Alkynols with N, O-Aminals

Lewis acid enables the electrophilic carbooxygenative cyclization of alkynols with N,O-aminals. The new process proceeds efficiently under very mild conditions via a pathway that is opposite to classical carbo-metalation. These reactions exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5-8-membered oxacycles bearing diverse functional groups. The cyclization products can be elaborated via simple functional group transformations to generate synthetically useful oxacycles.

Yttrium-Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium-Sized Lactams

An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, a mechanistic rationale for this novel cascade

Ti(O-i-Pr)4/Me3SiCl/Mg-mediated reductive cleavage of sulfonamides and sulfonates to amines and alcohols

A low-valent titanium generated in situ from Ti(O-i-Pr)4, Me3SiCl, and Mg powder in THF reacted with aryl- and alkyl-sulfonamides of aryl and alkyl amines in a reductive N-S/S-O/S-C bond cleaving pathway to provide the corresponding amines and hydrocarbons (and thiols) derived from the sulfonyl moiety. The reagent could also cleave sulfonates to the corresponding alcohols.

Gold-catalyzed direct activation of allylic alcohols in the stereoselective synthesis of functionalized 2-vinyl-morpholines

Alcohol versus alcohol: A highly stereocontrolled synthesis of substituted morpholines is realized by means of gold-catalyzed dehydrative allylic cyclization of diols (see scheme for one example; segphos = 5,5′-bis[di(3, 5-di-tert-butyl-4-methyoxyphenyl)phosphine]-4,4′-bi-1,3-benzodioxole). The present methodology represents one of the few examples of enantioselective gold-catalyzed transformations involving unactivated alkenes. Copyright