115340-08-4Relevant academic research and scientific papers
Synthesis of Medium-Sized Carbocycles by Gallium-Catalyzed Tandem Carbonyl-Olefin Metathesis/Transfer Hydrogenation
Djurovic, Alexandre,Vayer, Marie,Li, Zhilong,Guillot, Regis,Baltaze, Jean-Pierre,Gandon, Vincent,Bour, Christophe
, p. 8132 - 8137 (2019/10/14)
The first examples of a catalytic tandem process involving a ring-closing carbonyl-olefin metathesis and a transfer hydrogenation are described. 1,4-Cyclohexadiene has been used as an H2 surrogate to reduce the cyclic alkenes formed after the m
Chiral hetero- and carbocyclic compounds from the asymmetric hydrogenation of cyclic alkenes
Verendel, J. Johan,Li, Jia-Qi,Quan, Xu,Peters, Byron,Zhou, Taigang,Gautun, Odd R.,Govender, Thavendran,Andersson, Pher G.
, p. 6507 - 6513 (2012/06/29)
Several types of chiral hetero- and carbocyclic compounds have been synthesized by using the asymmetric hydrogenation of cyclic alkenes. N,P-Ligated iridium catalysts reduced six-membered cyclic alkenes with various substituents and heterofunctionality in good to excellent enantioselectivity, whereas the reduction of five-membered cyclic alkenes was generally less selective, giving modest enantiomeric excesses. The stereoselectivity of the hydrogenation depended more strongly on the substrate structure for the five- rather than the six-membered cyclic alkenes. The major enantiomer formed in the reduction of six-membered alkenes could be predicted from a selectivity model and isomeric alkenes had complementary enantioselectivity, giving opposite optical isomers upon hydrogenation. The utility of the reaction was demonstrated by using it as a key step in the preparation of chiral 1,3-cis-cyclohexane carboxylates. Copyright
Synthesis of Benzobicyclooctanes Involving Inversion of Configuration via an N to O Acetyl Migration
Grunewald, Gary L.,Ye, Qizhuang
, p. 4021 - 4026 (2007/10/02)
Two conformationally defined analogues of phenylethanolamine, 8-amino-6,7,8,9-tetrahydro-5,8-methano-5H-benzocyclohepten-endo-9-ol (5) and 8-amino-6,7,8,9-tetrahydro-5,8-methano-5H-benzocyclohepten-exo-9-ol (6), have been synthesized.The benzobicyclo3.2.
