115586-44-2Relevant articles and documents
Synthesis and Evaluation of (1S,2R/1R,2S)-Aminocyclohexylglycyl PNAs As Conformationally Preorganized PNA Analogues for DNA/RNA Recognition
Govindaraju,Kumar, Vaijayanti A.,Ganesh, Krishna N.
, p. 1858 - 1865 (2007/10/03)
Conformationally constrained cis-aminocyclohexylglycyl PNAs have been designed on the basis of stereospecific imposition of 1,2-cis-cyclohexyl moieties on the aminoethyl segment of aminoethylglycyl PNA (aegPNA). The introduction of the cis-cyclohexyl ring
(1S,2R/1R,2S)-aminocyclohexyl glycyl thymine PNA: Synthesis, monomer crystal structures, and DNA/RNA hybridization studies
Govindaraju,Gonnade, Rajesh G.,Bhadbhade, Mohan M.,Kumar, Vaijayanti A.,Ganesh, Krishna N.
, p. 3013 - 3016 (2007/10/03)
(Matrix Presented) The synthesis of ethyl cis-(1s,2R/1R,2S)-2.aminocyclohex-1-yI-N-(thymin-1-yl-acetyl) glycinate (10a and 10b) via enzymatic resolution of the key racemic intermediate trans-2-azido cyclohexanols 3 is reported. The crystal structures of 10 show equatorial disposition of the tertiary amide group, with the torsion angle β in the range 60-70°. The PNA oligomers incorporating these show differential effects in hybridizing with complementary DNA and RNA.
A NOVEL AND EFFICIENT SYNTHESIS OF (+)- AND (-)-TRANS-2-AMINOCYCLOHEXANOL BY ENZYMATIC HYDROLYSIS
Faber, Kurt,Hoenig, Helmut,Seufer-Wasserthal, Peter
, p. 1903 - 1904 (2007/10/02)
Both enantiomers of trans-2-aminocyclohexanol were obtained by enzimatic hydrolysis of (+/-)-2-azidocyclohexanoates using lipases and subsequent hydrogenation.
