115586-44-2

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 119479-49-1 (1S,2S)-trans-2-azidocyclohexanol 
• 121282-70-0 (1S,2S)-2-tert-Butoxycarbonylamino-1-cyclohexanol 
• 365996-29-8 (1R,2S)-2-(N-tert-butyloxycarbonylamino)-1-azidocyclohexane 
• 365996-30-1 tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate 
• 365996-28-7 (1S,2S)-2-(tert-butoxycarbonylamino)cyclohexyl methanesulfonate 
• 680591-65-5 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]glycine ethyl ester 
• 680591-66-6 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]-N-(chloroacetyl)glycine ethyl ester 
• 603128-72-9 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]-N-(thymin-1-ylacetyl)glycine ethyl ester 
• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 
• 155975-19-2 (1R,2R)-trans-2-(N-tert-butyloxycarbonyl)amino-1-cyclohexanol 
• 603128-65-0 (1S,2R)-2-(N-tert-butyloxycarbonylamino)-1-azidocyclohexane 
• 364385-54-6 (1S,2R)-2-tert-Butoxycarbonylamino-cyclohexylamine 
• 603128-64-9 (1R,2R)-2-(N-tert-butoxycarbonylamino)-cyclohexan-1-yl methanesulfonate 
• 603128-66-1 N-[(2R)-tert-butyloxycarbonylaminocyclohex-(1S)-yl]glycine ethyl ester 

Relevant academic research and scientific papers

Synthesis and Evaluation of (1S,2R/1R,2S)-Aminocyclohexylglycyl PNAs As Conformationally Preorganized PNA Analogues for DNA/RNA Recognition

Conformationally constrained cis-aminocyclohexylglycyl PNAs have been designed on the basis of stereospecific imposition of 1,2-cis-cyclohexyl moieties on the aminoethyl segment of aminoethylglycyl PNA (aegPNA). The introduction of the cis-cyclohexyl ring

(1S,2R/1R,2S)-aminocyclohexyl glycyl thymine PNA: Synthesis, monomer crystal structures, and DNA/RNA hybridization studies

(Matrix Presented) The synthesis of ethyl cis-(1s,2R/1R,2S)-2.aminocyclohex-1-yI-N-(thymin-1-yl-acetyl) glycinate (10a and 10b) via enzymatic resolution of the key racemic intermediate trans-2-azido cyclohexanols 3 is reported. The crystal structures of 10 show equatorial disposition of the tertiary amide group, with the torsion angle β in the range 60-70°. The PNA oligomers incorporating these show differential effects in hybridizing with complementary DNA and RNA.

A NOVEL AND EFFICIENT SYNTHESIS OF (+)- AND (-)-TRANS-2-AMINOCYCLOHEXANOL BY ENZYMATIC HYDROLYSIS

Both enantiomers of trans-2-aminocyclohexanol were obtained by enzimatic hydrolysis of (+/-)-2-azidocyclohexanoates using lipases and subsequent hydrogenation.