680591-65-5

Basic information

• Product Name: Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester
• CAS NO: 680591-65-5
• Molecular Formula: C15H28N2O4
• Molecular Weight: 300.398
• Mol File: 680591-65-5.mol

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester(680591-65-5)
• EPA Substance Registry System: Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester(680591-65-5)

Safety Data

• Hazardous Substances Data: 680591-65-5(Hazardous Substances Data)

Upstream product

• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 
• 365996-28-7 (1S,2S)-2-(tert-butoxycarbonylamino)cyclohexyl methanesulfonate 
• 365996-29-8 (1R,2S)-2-(N-tert-butyloxycarbonylamino)-1-azidocyclohexane 
• 115586-44-2 Butyric acid (1S,2S)-2-azido-cyclohexyl ester 
• 286-20-4 cyclohexane-1,2-epoxide 
• 119479-49-1 (1S,2S)-trans-2-azidocyclohexanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 105-36-2 ethyl bromoacetate 
• 365996-30-1 tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate 
• 121282-70-0 (1S,2S)-2-tert-Butoxycarbonylamino-1-cyclohexanol 

Downstream Products

• 603128-72-9 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]-N-(thymin-1-ylacetyl)glycine ethyl ester 
• 680591-66-6 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]-N-(chloroacetyl)glycine ethyl ester 

Relevant articles and documents

Synthesis and Evaluation of (1S,2R/1R,2S)-Aminocyclohexylglycyl PNAs As Conformationally Preorganized PNA Analogues for DNA/RNA Recognition

Conformationally constrained cis-aminocyclohexylglycyl PNAs have been designed on the basis of stereospecific imposition of 1,2-cis-cyclohexyl moieties on the aminoethyl segment of aminoethylglycyl PNA (aegPNA). The introduction of the cis-cyclohexyl ring

(1S,2R/1R,2S)-aminocyclohexyl glycyl thymine PNA: Synthesis, monomer crystal structures, and DNA/RNA hybridization studies

(Matrix Presented) The synthesis of ethyl cis-(1s,2R/1R,2S)-2.aminocyclohex-1-yI-N-(thymin-1-yl-acetyl) glycinate (10a and 10b) via enzymatic resolution of the key racemic intermediate trans-2-azido cyclohexanols 3 is reported. The crystal structures of 10 show equatorial disposition of the tertiary amide group, with the torsion angle β in the range 60-70°. The PNA oligomers incorporating these show differential effects in hybridizing with complementary DNA and RNA.