1158201-42-3

Basic information

• Product Name: N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide
• Synonyms: N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide
• CAS NO: 1158201-42-3
• Molecular Weight: 328.435
• Mol File: 1158201-42-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide(1158201-42-3)
• EPA Substance Registry System: N-1-[3-(1H-indol-3-yl)propyl]-4-methyl-1-benzenesulfonamide(1158201-42-3)

Safety Data

• Hazardous Substances Data: 1158201-42-3(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 7730-45-2 1-(toluene-4-sulfonyl)azetidine 
• 830-96-6 Indole-3-propionic acid 
• 5814-93-7 3-(3-indolyl)-propanamide 
• 25109-08-4 toluene-4-sulfonic acid 3-(1H-indol-3-yl)propyl ester 
• 70-55-3 toluene-4-sulfonamide 
• 3569-21-9 1H-indole-3-propanol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 59-88-1 phenylhydrazine hydrochloride 
• 6245-89-2 Homotryptamine 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Radical-Mediated Dearomatization of Indoles with Sulfinate Reagents for the Synthesis of Fluorinated Spirocyclic Indolines

The dearomative introduction of trifluoromethyl and 1,1-difluoroethyl radicals, generated from their corresponding sulfinate salts, into the C2 position of indole derivatives allows the diastereoselective synthesis of three-dimensional 3,3-spirocyclic indolines over C-H functionalized indoles.

A facile approach to spirocyclic 2-azido indolines via azidation of indoles with ceric ammonium nitrate

This paper describes azidation of indoles with NaN3 and ceric ammonium nitrate (CAN), giving a variety of spirocyclic 2-azido indolines in good yields and moderate diastereoselectivities.

Preparation method of spiro-2-azidoindoline

The invention provides a preparation method of a compound represented by the formula (III) or formula (IV). According to the preparation method, in an inert atmosphere, indoles represented by the formula (I) or (II), a precursor that can provide azido groups, and ceric ammonium nitrate carry out reactions to obtain the spiro-2-azidoindoline. In the formula (I), (II), (III), and (IV), the R1 represents at least one of hydrogen, a C1-C5 alkyl group, a C1-C5 alkyloxy group, F, Br and Cl; the X represents O or TsN, TsN represents p-toluenesulfonyl; and the R2 represents a C1-C5 alkyl group. The precursor is sodium azide or trimethylsilyl azide. The mole ratio of indoles represented by the formula (I) or (II) to precursor to ceric ammonium nitrate is 1:(1-3):(2-6). According to the preparation method, azide is introduced into an organic molecule through a simple method, namely, indoles with different structures are tank as the raw materials, and under the effects of a precursor that can provide azido groups and ceric ammonium nitrate, spiro-2-azidoindoline is successfully prepared. The provided method has the advantages of easily prepared raw materials, mild reaction conditions, and convenient operation, and the yield can reach 94%.