1159301-83-3Relevant academic research and scientific papers
PiB-conjugated, metal-based imaging probes: Multimodal approaches for the visualization of β-amyloid plaques
Martins, Andre F.,Morfin, Jean-Francois,Kubickova, Anna,Kubicek, Vojtech,Buron, Frederic,Suzenet, Franck,Salerno, Milena,Lazar, Adina N.,Duyckaerts, Charles,Arlicot, Nicolas,Guilloteau, Denis,Geraldes, Carlos F. G. C.,Toth, Eva
, p. 436 - 440 (2013)
In an effort toward the visualization of β-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of Aβ plaques, to DO3A-monoamide that is capable of forming
Gd3+ complexes conjugated to Pittsburgh compound B: Potential MRI markers of β-amyloid plaques Topical Issue on Metal-Based MRI Contrast Agents. Guest editor: Valerie C. Pierre
Martins, André F.,Morfin, Jean-Fran?ois,Geraldes, Carlos F. G. C.,Tóth, éva
, p. 281 - 295 (2014/03/21)
In an effort towards the visualization of β-amyloid (Aβ) plaques by T 1-weighted magnetic resonance imaging for detection of Alzheimer's disease, we report the synthesis and characterization of stable, noncharged Gd3+ complexes of th
Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents
Pan, Jinhe,Mason, Neale S.,Debnath, Manik L.,Mathis, Chester A.,Klunk, William E.,Lin, Kuo-Shyan
, p. 1720 - 1726 (2013/04/10)
To continue our efforts toward the development of 99mTc PiB analogs, we have synthesized 24 neutral and lipophilic Re (as a surrogate of 99mTc) 2-arylbenzothiazoles, and explored their structure-activity relationship for binding to Aβ1-40 fibrils. These Re complexes were designed and synthesized via the integrated approach, so their 99mTc analogs would have a greater chance of crossing the blood-brain barrier. While the lipophilicities (log PC18 = 1.59-3.53) of these Re 2-arylbenzothiazoles were all within suitable range, their binding affinities (Ki = 30-617 nM) to Aβ1-40 fibrils varied widely depending on the selection and integration of the tetradentate chelator into the 2-phenylbenzothiazole pharmacophore. For potential clinical applications, further refinement to obtain Re 2-arylbenzothiazoles with better binding affinities (99mTc analogs for more widespread application via the use of SPECT scanners.
Synthesis and β-amyloid binding properties of rhenium 2-phenylbenzothiazoles
Lin, Kuo-Shyan,Debnath, Manik L.,Mathis, Chester A.,Klunk, William E.
scheme or table, p. 2258 - 2262 (2009/12/03)
As a first step toward the development of 99mTc PiB analogs, we have synthesized six neutral Re 2-phenylbenzothiazoles via pendant or integrated approach. These Re compounds bind to Aβ1-40 fibrils with fairly good affinities (Ki
