43036-17-5

Usage

Chemical Properties

Yellow solid

Upstream product

• 43036-14-2 6-methoxy-2-(4-nitrophenyl)benzothiazole 
• 2942-13-4 6-methoxy-1,3-benzothiazole 
• 106-40-1 4-bromo-aniline 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 
• 24730-11-8 N-(4-methoxyphenyl)-4-nitrobenzamide 
• 104-94-9 4-methoxy-aniline 
• 150-13-0 4-amino-benzoic acid 
• 6274-29-9 2-amino-5-methoxy-thiophenol 
• 122-04-3 4-nitro-benzoyl chloride 
• 2941-58-4 2-bromo-6-methoxy-1,3 benzothiazole 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 7732-36-7 bis(2-amino-5-methoxyphenyl)disulfide 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 89415-43-0 (4-aminophenyl)boronic acid 

Downstream Products

• 178804-18-7 2-(4’-aminophenyl)-6-hydroxybenzothiazole 
• 178804-17-6 2-(4-amino-3-iodophenyl)-6-methoxybenzothiazole 
• 10205-71-7 4-(6-methoxybenzo[d]thiazol2-yl)-N,N-dimethylaniline 
• 247080-54-2 2-(4-amino-3-chlorophenyl)-6-methoxybenzothiazole 
• 247080-38-2 2-(4-amino-3-chloro-phenyl)-benzothiazol-6-ol 
• 401813-34-1 4-(6-methoxybenzo[d]thiazol-2-yl)-N-methylaniline 
• 1073610-35-1 4β-[4-(6-methoxy-1,3-benzothiazole-2-yl)anilino]-4-desoxypodophyllotoxin 
• 1073610-36-2 4'-O-demethyl-4β-[4-(6-methoxy-1,3-benzothiazole-2-yl)anilino]-4-desoxypodophyllotoxin 
• 1159301-83-3 2-(4’-chloroacetamide-phenyl)-6-methoxybenzothiazole 
• 1374349-54-8 N-[4-(6-methoxybenzo[d]thiazol-2-yl)phenyl]formamide 
• 1374349-45-7 N-[4-(6-methoxybenzo[d]thiazol-2-yl)phenyl]-N-(⁽¹¹⁾C-methyl)formamide 
• 1370531-54-6 N-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]-1-cyclopropanecarboxamide 
• 1370531-52-4 N,N'-dicyclohexyl-N''-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]guanidine 
• 1370531-53-5 N-benzyl-N'-[4-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]urea 

Relevant academic research and scientific papers

TARGETED ABERRANT ALPHA-SYNUCLEIN SPECIES AND INDUCED UBIQUITINATION AND PROTEOSOMAL CLEARANCE VIA CO-RECRUITMENT OF AN E3-LIGASE SYSTEM

Disclosed are bispecific compounds (degraders) that target α-synuclein protein for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat neurodegenerative diseases.

Metal-chelating benzothiazole multifunctional compounds for the modulation and 64Cu PET imaging of Aβ aggregation

While Alzheimer's Disease (AD) is the most common neurodegenerative disease, there is still a dearth of efficient therapeutic and diagnostic agents for this disorder. Reported herein are a series of new multifunctional compounds (MFCs) with appreciable affinity for amyloid aggregates that can be potentially used for both the modulation of Aβ aggregation and its toxicity, as well as positron emission tomography (PET) imaging of Aβ aggregates. Firstly, among the six compounds tested HYR-16 is shown to be capable to reroute the toxic Cu-mediated Aβ oligomerization into the formation of less toxic amyloid fibrils. In addition, HYR-16 can also alleviate the formation of reactive oxygen species (ROS) caused by Cu2+ ions through Fenton-like reactions. Secondly, these MFCs can be easily converted to PET imaging agents by pre-chelation with the 64Cu radioisotope, and the Cu complexes of HYR-4 and HYR-17 exhibit good fluorescent staining and radiolabeling of amyloid plaques both in vitro and ex vivo. Importantly, the 64Cu-labeled HYR-17 is shown to have a significant brain uptake of up to 0.99 ± 0.04 percentID per g. Overall, by evaluating the various properties of these MFCs valuable structure-activity relationships were obtained that should aid the design of improved therapeutic and diagnostic agents for AD. This journal is

Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers

A series of colchicine site binding tubulin inhibitors were synthesized by the modification of the combretastatin pharmacophore. The ring B was replaced by the pharmacologically relevant benzothiazole scaffolds, and the cis configuration of the olefinic b

2-Arylaminobenzothiazole-arylpropenone conjugates as tubulin polymerization inhibitors

A new series of 2-arylaminobenzothiazole-arylpropenone conjugates 5-6(a-r) was designed, synthesized and investigated for their cytotoxic potency against the various human cancer cell lines. Most of these conjugates exhibited cytotoxic activity and inhibi

Synthesis of 2-arylbenzothiazoles via direct condensation between in situ generated 2-aminothiophenol from disulfide cleavage and carboxylic acids

In this work we describe a simple and efficient general methodology for 2-arylbenzothiazole preparation employing disulfides and carboxylic acids. The reaction is promoted by tributylphosphine that acts both in disulfide bond cleavage and as activating agent for coupling with carboxylic acids. The reaction scope was studied using bis(2-aminophenyl)disulfide and different carboxylic acids with donor/withdrawing substituents, which resulted in the desired 2-arylbenzothiazole with moderate to good yields. The method was tested with success in preparation of the amyloid probe 2-(4-aminophenyl)-6-methoxybenzothiazole that employed a substituted bis(2-aminophenyl)disulfide.

Design, synthesis and antimetastatic evaluation of 1-benzothiazolylphenylbenzotriazoles for photodynamic therapy in oral cancer cells

We have designed and synthesized a new series of 1-benzothiazolylphenylbenzotriazoles 9a-p and studied their antimetastatic mechanism involved in photosensitive effects induced by UVA in oral cancer cell Ca9-22. Our results revealed that the compounds plus UVA significantly suppressed migration and invasion, as detected by wound healing assay and Boyden chamber assay. Quantitative RT-PCR assay indicated that compound 9i plus UVA induced an antimetastatic effect through up-regulation of syndecan-1 and TIMP-3 and down-regulation of heparanase, MMP-2 and MMP-9 mRNA expressions. Western blot analysis showed that Ca9-22 treated with 9i plus UVA resulted in decreased levels of p-EGFR and p-ERK, MMP-2 and MMP-9, and an increased level of TIMP-3. These results are the first to report the function of UVA-activated 1-benzothiazolylphenylbenzotriazoles in tumor metastasis and their underlying molecular mechanism, and thus suggest that compound 9i plus PDT may serve as a potential ancillary modality for the treatment of oral cancer.

For nerve degenerative disease is in the field of PET imaging agent precursor and the standard method for the synthesis of (by machine translation)

A novel PET imaging agent precursor and standard and its preparation method, in order to 4-nitro cinnamic aldehyde, the methoxylphenylboronic ethylamine as a reaction initiator, synthesis of the precursor (compound 10) 4 - (6 - (2-P-toluene-sulfonic acid ethoxycarbonyl)-oxy-2-quinolyl)-N-tert-butoxy-carbonyl-N-n-pentyl-( [N-methyl-N-tert-butoxy carbonyl] - 2 - [4 ˊ - (methylamino) phenyl]-benzothiazole aniline) - 6-ether) aniline and standard (compound 25) 4 - (6 - (2-F)-oxy-2-quinolyl)-N-n-pentyl-( [N-methyl] - 2 - [4 ˊ - (methylamino) phenyl]-benzothiazole aniline) - 6-ether) aniline, at the same time provides A β protein specific binding agent 11 C-6-OH-BTA-1 an important intermediate for preparing (compound 7) method for the preparation of, the preparation method is a brand new synthetic route, step is simple, moderate reaction. (by machine translation)

Synthesis of 2-(4-aminophenyl)benzothiazoles using MF resin supported H+ under solvent free conditions

Abstract A simple and convenient approach to 2-(4-aminophenyl)benzothiazole derivatives by condensation of o-aminothiophenol with (un)substituted p-aminobenzoic acid under the action of melamine formaldehyde resin (MFR) supported sulfuric acid under microwave irradiation (MW) and solvent-free conditions has been developed. Structures of the corresponding products were elucidated by IR, 1H NMR spectra, and elemental analysis. The resin could be easily recovered and reused for subsequent reactions.

The flocculated acryloyldimethyltauric molecule ligand

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Gd3+ complexes conjugated to Pittsburgh compound B: Potential MRI markers of β-amyloid plaques Topical Issue on Metal-Based MRI Contrast Agents. Guest editor: Valerie C. Pierre

In an effort towards the visualization of β-amyloid (Aβ) plaques by T 1-weighted magnetic resonance imaging for detection of Alzheimer's disease, we report the synthesis and characterization of stable, noncharged Gd3+ complexes of th