1159987-56-0Relevant academic research and scientific papers
Cu-catalyzed cyclization to construct indoles fromN-(ortho-chloromethyl)aryl carbamates and terminal alkynesviaa one-pot reaction
Shi, Yang,Wang, Gangqiang,Wang, Hang,Deng, Bin,Gao, Tao,Wang, Jian,Guo, Haibing,Wu, Minghu,Sun, Shaofa
, p. 14477 - 14480 (2020)
In this reaction, a new strategy for the synthesis of indoles fromN-(ortho-chloromethyl)aryl carbamates and terminal alkynesviaCu-catalyzed coupling-cyclization has been developed. The reactions proceeded smoothly under mild conditions with a wide functional group tolerance.
A Synthetic Route to Chiral Benzo-Fused N-Heterocycles via Sequential Intramolecular Hydroamination and Asymmetric Hydrogenation of Anilino-Alkynes
Xu, Cong,Feng, Yu,Li, Faju,Han, Jiahong,He, Yan-Mei,Fan, Qing-Hua
supporting information, p. 3979 - 3990 (2019/11/14)
An efficient sequential intramolecular hydroamination/asymmetric hydrogenation reaction under catalysis of a single chiral ruthenium complex or a binary system consisting of achiral gold complex and chiral ruthenium complex has been reported. A diverse range of enantioenriched benzo-fused N-heterocycles, including 1,2,3,4-tetrahydroquinoline, indoline, and 2,3,4,5-tetrahydro-1H-benzo[b]azepine derivatives, were obtained from anilino-alkynes in high yields (up to 98%) with moderate to excellent enantioselectivities (up to 98% ee) under mild conditions. This protocol features good functional group tolerance and high atom economy. Furthermore, this catalytic protocol is applicable to gram-scale synthesis of a naturally occurring alkaloid, (-)-Angustureine.
Consecutive intramolecular hydroamination/asymmetric transfer hydrogenation under relay catalysis of an achiral gold complex/chiral Bronsted acid binary system
Han, Zhi-Yong,Xiao, Han,Chen, Xiao-Hua,Gong, Liu-Zhu
supporting information; experimental part, p. 9182 - 9183 (2009/12/06)
(Chemical Equation Presented) Consecutive hydroamination/asymmetric transfer hydrogenation under relay catalysis of an achiral gold complex/chiral Bronsted acid binary system has been described for the direct transformation of 2-(2-propynyl)aniline deriva
