116016-56-9

Usage

Uses

Used in Organic Chemistry:
5-(4-Methoxyphenyl)-2-thiophenecarboxylic Acid is used as a building block for the synthesis of various organic compounds due to its distinctive molecular structure and reactivity. The presence of the thiophene ring and the 4-methoxyphenyl group allows for versatile chemical reactions, making it a valuable intermediate in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-(4-Methoxyphenyl)-2-thiophenecarboxylic Acid is used as a key intermediate in the development of new drugs. Its unique structure can be modified to create novel therapeutic agents with potential applications in treating various diseases, including but not limited to cardiovascular, neurological, and inflammatory conditions.
Used in Agrochemical Industry:
5-(4-Methoxyphenyl)-2-thiophenecarboxylic Acid is utilized as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the creation of compounds that can effectively control pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Material Science:
In the field of material science, 5-(4-Methoxyphenyl)-2-thiophenecarboxylic Acid is employed in the development of advanced materials with specific properties. Its incorporation into polymers and other materials can enhance their electrical conductivity, thermal stability, or mechanical strength, making them suitable for applications in electronics, aerospace, and other high-tech industries.

InChI:InChI=1/C12H10O3S/c1-15-9-4-2-8(3-5-9)10-6-7-11(16-10)12(13)14/h2-7H,1H3,(H,13,14)

Upstream product

• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 5720-07-0 4-methoxyphenylboronic acid 
• 69202-21-7 5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester 
• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 116016-50-3 2-mercapto-5-(p-methoxyphenyl)-2,4-pentadienoic acid 
• 116016-55-8 2,2,-dithiobis<5-(p-methoxyphenyl)-2,4-pentanedioic acid> 
• 15328-92-4 5-(p-methoxycinnamylidene)rhodanine 

Downstream Products

• 116016-57-0 5-p-hydroxyphenyl-2-thenoic acid 

Relevant academic research and scientific papers

Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents

5-phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound 7 was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To discover antifungal agents with a broad spectrum and improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of 4-phenyl-4,5-dihydrooxazole derivatives were designed and synthesized. It was especially encouraging that compound 22a displayed significant antifungal activities against eight susceptible strains and seven FLC-resistant strains. Furthermore, the potent compound 22a could prevent the formation of fungalbiofilms and displayed satisfactory fungicidal activity. In addition, the metabolic stability of compound 22a was improved significantly, with the half-life of 70.5 min. Compound 22a was almost nontoxic to mammalian A549, MCF-7, HepG2, and 293T cells. Moreover, pharmacokinetic studies in SD rats showed that compound 22a exhibited pharmacokinetic properties with a bioavailability of 15.22% and a half-life of 4.44 h, indicating that compound 22a is worthy of further study.

Hedgehog signal pathway inhibitor

The invention provides a Hedgehog signal pathway inhibitor as well as stereoisomers, tautomers, hydrates, solvates or pharmaceutically acceptable salts thereof, and the structural formula of the inhibitor is as shown in a formula (I). The invention further provides a preparation method and application of a compound. The compound provided by the invention is novel in structure; a signal transduction pathway adjusted by Hedgehog protein, Ptch, Gli and/or Smo can be adjusted through the compound of the formula I.

Synthesis of Unsymmetrical Arylthiophenes and Bithienyls via Oxidative Cyclization of 1,3-Butadiene-1-thiols

Oxidative cyclization of 2-mercapto-5-aryl-2,4-pentanedienoic acids with iodine produced the respective 5-aryl-2-thenoic acids.The method was also suitable for the synthesis of unsymmetrical substituted 2,2,-bithienyls, and 2,3'-bithienyls.The synthesis o