1160293-22-0

Basic information

• Product Name: 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester
• Synonyms: 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester;(Z)-Methyl 3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate;3-(Methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;(E)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;methyl (Z)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
• CAS NO: 1160293-22-0
• Molecular Formula: C₁₈H₁₅NO₄
• Molecular Weight: 309.316
• Product Categories: Intermediate of BIBF-1120 and PKI587
• Mol File: 1160293-22-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 523.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.273±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.62±0.20(Predicted)
• CAS DataBase Reference: 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester(1160293-22-0)
• EPA Substance Registry System: 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester(1160293-22-0)

Safety Data

• Hazardous Substances Data: 1160293-22-0(Hazardous Substances Data)

Usage

Uses

(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.

Upstream product

• 1235004-99-5 methyl 2-oxoindole-6-carboxylate 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 1160293-27-5 [4-(methoxycarbonyl)-2-nitrophenyl]malonic acid dimethyl ester 
• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 1160293-25-3 methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate 
• 618-95-1 methyl 3-nitrobenzoate 
• 121-92-6 3-nitrobenzoic acid 
• 14192-26-8 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 
• 334952-07-7 4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester 
• 1160293-24-2 N-chloroacetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 

Downstream Products

• 656247-17-5 nintedanib 
• 1987887-92-2 methyl (Z)-3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 
• 1160294-26-7 nintedanib 

Relevant articles and documents

Impurity compound of Nintedanib, as well as preparation method, application and detection method of impurity compound

The invention relates to an impurity compound of Nintedanib, as well as a preparation method, application and detection method of the impurity compound. The structure of the impurity compound is shown in the following formula I (as shown in the specification), or in the following formula II (as shown in the specification). The invention aims to improve the quality standard of Nintedanib through study on impurities to guarantee the safe medication of Nintedanib. According to the preparation method disclosed by the invention, the pure impurity compound of Nintedanib is obtained, so that a reference substance for qualitative and quantitative analysis is provided for the detection of a finished Nintedanib product.

nepal reaches Neeb process and intermediates for the synthesis of (by machine translation)

The invention discloses a method for synthesizing nepal reaches Neeb and intermediates thereof, the synthesis method comprises: under acidic conditions, the compound of formula (II) reaction of a compound of the formula (I) compound of formula (III); compound (III) of the detached with acid uncle Ding Zhiji carbonate, adding alkali reaction of the compound of formula (V); the compound of formula (V) reaction with chloroacetic acid derivatives of formula (VI) the activation of the compound, then the reaction-methyl piperazine N, obtain nepal reaches Neeb. The present invention provides a mild reaction conditions of a new method for synthesizing nepal reaches Neeb, the invention also provides synthetic intermediates nepal reaches Neeb. (by machine translation)

INDOLINONE DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE

The present invention relates to specific indolinone derivatives, namely the compounds of formula, in which R1 represents an hydrogen atom or a group, and R2 and R3 each represent an hydrogen atom or R2 and R3 taken together represent a group, with the proviso that when R1 represents an hydrogen atom R2 and R3 taken together represent a group, and to a process for their manufacture.