1160293-27-5

Usage

Uses

Used in Pharmaceutical Industry:
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate is used as an intermediate in the synthesis of pharmaceuticals for its reaction capabilities and as a starting material for the production of various esters and nitrophenyl compounds.
Used in Research and Development:
In the field of research and development, 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate is utilized for its reaction capabilities, serving as a starting material for the production of various organic compounds.
Safety Measures:
As with any chemical, appropriate safety measures should be followed when handling, storing, and using 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate to prevent exposure and minimize risks.

Upstream product

• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 108-59-8 malonic acid dimethyl ester 
• 96-99-1 4-chloro-3-nitrobenzoate 

Downstream Products

• 199328-10-4 methyl 2-oxoindoline-5-carboxylate 
• 1160293-25-3 methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate 
• 1160293-24-2 N-chloroacetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 
• 1160293-22-0 3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 
• 1987887-92-2 methyl (Z)-3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 
• 656247-17-5 nintedanib 

Relevant academic research and scientific papers

Preparation of 6-methoxyl carbonyl-2-oxo-indoline

The invention belongs to the field of pharmaceutical chemistry, and relates to a preparation process of a nintedanib esilate intermediate 6-methoxyl carbonyl-2-oxo-indoline. The process solves the problems of relatively low yield of intermediates and high cost, is convenient for large-scale production, and simultaneously avoids protection of other patents.

nepal reaches Neeb process and intermediates for the synthesis of (by machine translation)

The invention discloses a method for synthesizing nepal reaches Neeb and intermediates thereof, the synthesis method comprises: under acidic conditions, the compound of formula (II) reaction of a compound of the formula (I) compound of formula (III); compound (III) of the detached with acid uncle Ding Zhiji carbonate, adding alkali reaction of the compound of formula (V); the compound of formula (V) reaction with chloroacetic acid derivatives of formula (VI) the activation of the compound, then the reaction-methyl piperazine N, obtain nepal reaches Neeb. The present invention provides a mild reaction conditions of a new method for synthesizing nepal reaches Neeb, the invention also provides synthetic intermediates nepal reaches Neeb. (by machine translation)

INDOLINONE DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE

The present invention relates to specific indolinone derivatives, namely the compounds of formula, in which R1 represents an hydrogen atom or a group, and R2 and R3 each represent an hydrogen atom or R2 and R3 taken together represent a group, with the proviso that when R1 represents an hydrogen atom R2 and R3 taken together represent a group, and to a process for their manufacture.

PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.