1160293-27-5

Basic information

• Product Name: 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate
• Synonyms: 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate;dimethyl 2-(4-methoxycarbonyl-2-nitrophenyl)propanedioate;methyl 4-(di(methoxycarbonyl)methyl)-3-nitrobenzoate;2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioic acid 1,3-dimethyl ester;[4-(methoxycarbonyl)-2-nitrophenyl]-propanedioic acid dimethyl ester;dimethyl 2-(4-(methoxycarbonyl)-2-nitrophenyl)malonate;Intedanib Impurity 3
• CAS NO: 1160293-27-5
• Molecular Formula: C₁₃H₁₃NO₈
• Molecular Weight: 311.24422
• Mol File: 1160293-27-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 433.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.357±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 9.81±0.46(Predicted)
• CAS DataBase Reference: 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate(1160293-27-5)
• EPA Substance Registry System: 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate(1160293-27-5)

Safety Data

• Hazardous Substances Data: 1160293-27-5(Hazardous Substances Data)

Usage

General Description

Structure and Properties: The chemical compound 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate is an ester with the molecular formula C13H15NO7. It consists of a 2-nitrophenyl group and a methoxycarbonyl group attached to a propanedioate backbone. 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate is a yellow crystalline powder with a molecular weight of 297.26 g/mol. It is insoluble in water but soluble in organic solvents such as ethanol and dichloromethane. Uses: 1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also used in research and development for its reaction capabilities and as a starting material for the production of various esters and nitrophenyl compounds. As with any chemical, appropriate safety measures should be followed when handling, storing, and using this compound to prevent exposure and minimize risks.

Upstream product

• 14719-83-6 methyl 3-nitro-4-chlorobenzoate 
• 108-59-8 malonic acid dimethyl ester 
• 96-99-1 4-chloro-3-nitrobenzoate 

Downstream Products

• 199328-10-4 methyl 2-oxoindoline-5-carboxylate 
• 1160293-25-3 methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate 
• 1160293-24-2 N-chloroacetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 
• 1160293-22-0 3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 
• 1987887-92-2 methyl (Z)-3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 
• 656247-17-5 nintedanib 

Relevant articles and documents

Preparation of 6-methoxyl carbonyl-2-oxo-indoline

The invention belongs to the field of pharmaceutical chemistry, and relates to a preparation process of a nintedanib esilate intermediate 6-methoxyl carbonyl-2-oxo-indoline. The process solves the problems of relatively low yield of intermediates and high cost, is convenient for large-scale production, and simultaneously avoids protection of other patents.

INDOLINONE DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE

The present invention relates to specific indolinone derivatives, namely the compounds of formula, in which R1 represents an hydrogen atom or a group, and R2 and R3 each represent an hydrogen atom or R2 and R3 taken together represent a group, with the proviso that when R1 represents an hydrogen atom R2 and R3 taken together represent a group, and to a process for their manufacture.