116143-06-7

Upstream product

• 51-35-4 4-hydroxyproline 
• 132666-67-2 (2S,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate 
• 116143-05-6 allo-1-(4-tolylsulfonyl)-4-<<(4-methylphenyl)sulfonyl>oxy>-D-proline ethyl ester 
• 127-08-2 potassium acetate 
• 2584-71-6 cis-hydroxy-D-proline 
• 51-35-4 4R-4-hydroxyproline 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 77449-99-1 (2R,4R)-2-ethoxycarbonyl-4-hydroxypyrrolidine hydrochloride 
• 10534-59-5 tetrabutylammonium acetate 
• 1185-59-7 tetraethylammonium acetate 
• 10581-12-1 tetramethyl ammonium acetate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1075183-51-5 N-tosyl hydroxyproline methyl ester 
• 1076206-66-0 (1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane 
• 1076206-60-4 (2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol 
• 1076206-58-0 (4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-D-proline methyl ester 
• 1076206-64-8 (1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane 
• 142928-26-5 (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<(3,5-dimethyl-1H-pyrazol-1-yl)-carbonyl>pyrrolidine 
• 116143-32-9 7-<(1R,4R)-2,5-diazabicyclo<2.2.1>heptan-2-yl>-1-(1,1-dimethylethyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 116258-17-4 (1R,4R)-5-phenylmethyl-2,5-diazabicyclo[2.2.1] heptane dihydrobromide 
• 118354-72-6 (1R,4R)-2-(4-tolylsulfonyl)-5-(phenylmethyl)-2,5-diazabicyclo<2.2.1>heptane 
• 116143-09-0 (3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine 
• 125224-63-7 (1R,4R)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane 
• 114086-15-6 (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide 
• 141621-11-6 (2R,4S,1'R)-1-(4-tolylsulfonyl)-2-(1-hydroxyethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>pyrrolidine 
• 141621-12-7 (2R,4S,1'S)-1-(4-tolylsulfonyl)-2-(1-hydroxyethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>pyrrolidine 

Relevant academic research and scientific papers

FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES

Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.

Azadideoxyadenosine: Synthesis, enzymology, and anti-HIV activity

Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian adenosine deaminase and it is a substrate for adenosine kinase. It exhibits in vitro anti-HIV activity.

PREPARATION OF (6R)- AND (6S)-(1R,4R)-6-METHYL-2-(p-TOLUENESULFONYL)-5-PHENYLMETHYL-2,5-DIAZABICYCLOHEPTANES, INTERMEDIATES IN A SYNTHESIS OF NEW QUINOLONES

An efficjent chiral synthesis of both diastereoisomers (2a) and (2b) was preformed using trans-4-hydroxy-L-proline as starting material.These bridged piperazines were used in the preparation of quinolones.

Fluoronaphthyridines and Quinolones as Antibacterial Agents. 2. Synthesis and Structure-Activity Relationships of New 1-tert-Butyl 7-Substituted Derivatives

A number of 7-substituted-1-tert-butyl-6-fluoroquinolone-3-carboxylic acids and 7-substituted-1-tert-butyl-6-fluoro-1,8-naphthyridine-3-carboxylic acids have been prepared and tested for antibacterial activities.Among those the 7-aminopyrrolidinyl 20b and