1161570-47-3Relevant academic research and scientific papers
RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays
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, (2016/02/26)
The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Fur
Acetal Levulinyl Ester (ALE) groups for 2′-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays
Lackey, Jeremy G.,Mitra, Debbie,Somoza, Mark M.,Cerrina, Franco,Damha, Masad J.
supporting information; experimental part, p. 8496 - 8502 (2009/10/23)
We describe a synthetic strategy that permits both the growth and deprotection of RNA chains that remain attached to a solid polymer support or chip surface. The key synthons for RNA synthesis are novel 5′-O-DMTr 2′-acetal levulinyl ester (2′-O-ALE) ribon
