116529-78-3

Usage

Uses

Used in Chemical Synthesis:
2-Phenyl-8-aminoquinoline is used as a chemical intermediate for the synthesis of various compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the development of new molecules with potential applications in different industries.
Used in Pharmaceutical Research:
2-Phenyl-8-aminoquinoline is used as a research compound in the field of pharmaceuticals. Its structure and properties make it a promising candidate for the development of new drugs, particularly in the areas of medicinal chemistry and drug discovery. Researchers can explore its potential interactions with biological targets and assess its efficacy in treating various diseases.
Used in Material Science:
2-Phenyl-8-aminoquinoline is used as a component in the development of new materials. Its chemical properties may contribute to the creation of advanced materials with unique characteristics, such as improved stability, enhanced reactivity, or novel optical and electronic properties, which can be applied in various technological applications.
Used in Analytical Chemistry:
2-Phenyl-8-aminoquinoline is used as an analytical reagent in various chemical analyses. Its distinctive chemical properties can be exploited to develop new analytical methods or improve existing ones, allowing for more accurate and efficient detection and quantification of target compounds in complex samples.

Upstream product

• 88-74-4 2-nitro-aniline 
• 100-52-7 benzaldehyde 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 
• 109-92-2 ethyl vinyl ether 
• 104-55-2 3-phenyl-propenal 
• 1312835-41-8 C₉H₇BrN₂ 
• 98-80-6 phenylboronic acid 
• 6961-25-7 2-phenyl-8-hydroxy-quinoline 
• 148-24-3 8-quinolinol 
• 5093-81-2 2-phenylquinoline-8-carboxylic acid 
• 5353-90-2 8-methyl-2-phenylquinoline 
• 14371-10-9 (E)-3-phenylpropenal 
• 25771-64-6 8-nitro-2-phenylquinoline 

Downstream Products

• 25677-69-4 2,9-diphenyl-1,10-phenanthroline 
• 109559-47-9 2-phenyl-1,10-phananthroline 
• 1263175-14-9 2-isopropyl-9-phenyl-[1,10]phenanthroline 
• 1375158-97-6 C₉H₅C₆H₅NNCCH₃CHCOHCH₃ 
• 1426561-53-6 2-((2-phenylquinolin-8-ylamino)methyl)phenol 
• 1426561-56-9 2-(((2-hydroxybenzyl)(2-phenylquinolin-8-yl)amino)methyl)-4-nitrophenol 

Relevant academic research and scientific papers

Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in α of the nitrogen has been performed through an inverse-demanding aza-Diels-Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.

Nitrogen-containing organic compound, application, and organic electroluminescent device using same

The invention relates to a nitrogen-containing organic compound, an application thereof and an organic electroluminescent device using the same. The chemical structure of the nitrogen-containing organic compound takes pyridinoquinazoline as the center, wh

Transition-Metal-Free Regioselective C–H Bond Fluorination of 8-Amidoquinolines with Selectfluor

A simple and efficient transition-metal-free protocol for the regioselective C–H bond fluorination of 8-aminoquinoline scaffolds with Selectfluor was developed. The reaction has a broad substrate scope and provides facile access to the corresponding C-5 f

QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Synthesis and structures of tridentate ketoiminate zinc complexes that act as l-lactide ring-opening polymerization catalysts

A series of NNO tridentate Schiff base ligands were used to prepare zinc amide and zinc phenoxide complexes that were shown to be efficient l-lactide ring-opening polymerization (ROP) catalysts. The complexes were prepared from ketoimines bearing a pendant quinoline donor, zinc bis(trimethylsilyl)amide, and 2,6-di-tert-butylphenol. They were characterized with 1H and 13C NMR, absorbance spectroscopy, microanalysis, and X-ray crystallography. The zinc amide and zinc phenoxide structures showed mononuclear complexes with tridentate coordination by the ketoiminate ligands. ROP of l-lactide with the zinc amides and phenoxide complexes gave isotactic poly-l-lactide with generally low molecular weight distributions. As compared to their amide counterparts, the zinc phenoxide complexes showed superior lactide ROP behavior in terms of percent conversion as a function of time, measured molecular weights closer to the predicted values, and lower polydispersity index values. Increasing size of the substituent at the 2-position on quinoline (H, Me, Ph) improved the synthesis of the complexes but adversely affected the ROP.