116569-68-7

Upstream product

• 112-16-3 n-dodecanoyl chloride 
• 118-92-3 anthranilic acid 
• 134-20-3 2-carbomethoxyaniline 
• 150225-96-0 methyl lauroylanthranilate 

Relevant academic research and scientific papers

New 2,3-disubstituted quinazolin-4(3H)-ones from 2-undecyl-3,1-benzoxazin- 4-one

2-undecyl-4H-3,1-benzoxazin-4-one (2) was prepared and reacted with primary and secondary amines affording compounds 3-7, while with hydrazine hydrate it gave the quinazolinone derivative 8. The reaction of 8 with 3,4,5- trimethoxybenzaldehyde followed by

Ortho-aminobenzoic acid derivative and application thereof

The invention relates to the technical field of cosmetics and medicines, in particular to an ortho-aminobenzoic acid derivative compound and application thereof. By preparing a series of compounds with an anti-inflammatory function, the obtained anti-inflammatory compound can be used for preparing cosmetic reagents or pharmaceutical reagents, and the cosmetic reagents and the pharmaceutical reagents are not specifically limited. For example, the cosmetic can be a smoothing toner, a nutritional toner, a massage cream, an emollient, a gel, a nutritional cream, a mask, a gel or a shower gel shampoo and other washing type cosmetics, and can also be a cream, ointment, cream, plaster or spray and other similar pharmaceutical preparation products. The compound can be used for a sensitive skin andcan also be added to infant and child cosmetics to reduce irritation.

Inhibition of PCAF histone acetyltransferase and cytotoxic effect of N-acylanthranilic acids

Small molecule HAT inhibitors are useful tools to unravel the role of histone acetyltransferases (HATs) in the cell and have relevance for oncology. We synthesized a series of N-acylanthranilic acids (11-16) and of N-acyl-5-hydroxyanthranilic acids (17-22) bearing C6, C8, C10, C12, C14, along with C16 acyl chain at the 2-amino position of anthranilic acid or 5-hydroxyanthranilic acid. Enzyme inhibition of these compounds was investigated, using in vitro PCAF HAT assays. All synthesized compounds (65-76%) showed similar inhibitory activity to anacardic acid (68%) at 100 μM. The cytotoxicity, against one normal cell line (HSF) and eight cancer cell lines (HT-29, HCT-116, MDA-231, A-549, Hep3B, Caski, HeLa and Caki), were evaluated by the SRB method.

INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

The present invention relates to the use of compounds as broad spectrum inhibitors of bacterial biofilm formation. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative and Gram-positive bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of bacterial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.