1167056-71-4 Usage
Uses
Used in Pharmaceutical Synthesis:
Methyl 6-nitro-1H-indazole-3-carboxylate is used as a building block for the preparation of various indazole derivatives in the pharmaceutical industry. Its unique structure and properties allow for the development of new drugs with potential therapeutic applications.
Used in Drug Discovery and Development:
In the field of drug discovery and development, Methyl 6-nitro-1H-indazole-3-carboxylate is employed as a starting material for the synthesis of compounds with potential biological and pharmacological activities. Its versatility and reactivity make it a promising candidate for the creation of novel therapeutic agents.
Used in Organic Synthesis and Medicinal Chemistry Research:
Methyl 6-nitro-1H-indazole-3-carboxylate serves as a reagent in organic synthesis, enabling the preparation of a wide range of chemical compounds. In medicinal chemistry research, it is used to explore its potential as a precursor for the development of new pharmaceuticals and to study its interactions with biological targets.
Used in Chemical Compounds Industry:
Methyl 6-nitro-1H-indazole-3-carboxylate is used as a key component in the synthesis of various chemical compounds, particularly those with potential applications in the pharmaceutical sector. Its unique properties and reactivity contribute to the development of innovative and effective products in this industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1167056-71-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,6,7,0,5 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1167056-71:
(9*1)+(8*1)+(7*6)+(6*7)+(5*0)+(4*5)+(3*6)+(2*7)+(1*1)=154
154 % 10 = 4
So 1167056-71-4 is a valid CAS Registry Number.
1167056-71-4Relevant articles and documents
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase
Crocetti, Letizia,Schepetkin, Igor A.,Cilibrizzi, Agostino,Graziano, Alessia,Vergelli, Claudia,Giomi, Donatella,Khlebnikov, Andrei I.,Quinn, Mark T.,Giovannoni, Maria Paola
, p. 6259 - 6272 (2013/09/02)
Human neutrophil elastase (HNE) is an important therapeutic target for treatment of pulmonary diseases. Previously, we identified novel N-benzoylindazole derivatives as potent, competitive, and pseudoirreversible HNE inhibitors. Here, we report further development of these inhibitors with improved potency, protease selectivity, and stability compared to our previous leads. Introduction of a variety of substituents at position 5 of the indazole resulted in the potent inhibitor 20f (IC50 ～10 nM) and modifications at position 3 resulted the most potent compound in this series, the 3-CN derivative 5b (IC50 = 7 nM); both derivatives demonstrated good stability and specificity for HNE versus other serine proteases. Molecular docking of selected N-benzoylindazoles into the HNE binding domain suggested that inhibitory activity depended on geometry of the ligand-enzyme complexes. Indeed, the ability of a ligand to form a Michaelis complex and favorable conditions for proton transfer between Hys57, Asp102, and Ser195 both affected activity.
Synthesis of 3-indazolecarboxylic esters and amides via Pd-catalyzed carbonylation of 3-iodoindazoles
Buchstaller, Hans-Peter,Wilkinson, Kai,Burek, Kasimir,Nisar, Yasmin
experimental part, p. 3089 - 3098 (2011/10/13)
A straightforward and effective procedure for the preparation of 1H-indazole-3-carboxylic acid esters and amides was developed. A series of functionalized 3-iodoindazoles were subjected to Pd-catalyzed carbonylations in the presence of methanol or amines,
