116725-92-9Relevant academic research and scientific papers
Quinolizidines. XXXIII. A chiral synthesis of (-)-ophiorrhizine, a pentacyclic quaternary indole alkaloid from ophiorrhiza major RIDL
Fujii,Ohba,Seto
, p. 49 - 52 (2007/10/02)
A detailed account is given of the first chiral synthesis of the Ophiorrhiza alkaloid ophiorrhizine [(-)-1]. The synthesis was started by coupling the lactim ether (+)-4, readily available from cincholoipon ethyl ester [(+)-3], with 6-benzyloxy-3-chloroac
Absolute Stereochemistry of the Pentacyclic Quaternary Indole Alkaloid Ophiorrhizine: Synthetic Incorporation of Cincholoipon Ethyl Ester Into (-)-Ophiorrhizine
Ohba, Masashi,Seto, Shigeki,Fujii, Tozo,Sargent, Melvyn V.,Arbain, Dayar
, p. 1741 - 1744 (2007/10/02)
The absolute stereochemistry of the Ophiorrhiza alkaloid ophiorrhizine has been defined as shown in formula by a chemical correlation with the Cinchona alkaloid cinchonine through cincholoipon ethyl ester and the lacitim ether .The
Topsentin compounds effective against viruses and certain tumors
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, (2008/06/13)
A new class of novel, biologically active bisindole alkaloid compounds, which have been named topsentins, pharmaceutical compositions containing them, methods of producing the compounds and methods of using them are disclosed. This new class of compounds
Topsentin, Bromotopsentin, and Dihydrodeoxybromotopsentin: Antiviral and Antitumor Bis(indolyl)imidazoles from Caribbean Deep-Sea Sponges of the Family Halichondriidae Structural and Synthetic Studies
Tsujii, Shinji,Rinehart, Kenneth L.,Gunasekera, Sarath P.,Kashman, Yoel,Cross, Susan S.,et al.
, p. 5446 - 5453 (2007/10/02)
Isolation and structure elucidation of topsentin (1) and bromotopsentin (2) are described.These novel indole alkaloids have been shown to have antitumor and antiviral activities.Their structures were determined on the basis of spectral data, and bromotopsentin was correlated structurally with topsentin by catalytic debromination.Syntheses of 1 and several analogues are also reported.
