116855-49-3

Upstream product

• 24544-04-5 2,6-diisopropylbenzenamine 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 20781-86-6 N-(2,6-diisopropylphenyl)-2-chloroacetamide 
• 116855-48-2 2-(diethylamino)-N-<2,6-bis(1-methylethyl)phenyl>acetamide 

Downstream Products

• 116855-63-1 N-<2-(diethylamino)ethyl>-N-<2,6-bis(1-methylethyl)phenyl>-4-<(methylsulfonyl)amino>benzamide hydrochloride 

Relevant academic research and scientific papers

Versatile Bulky N,N′,N′-Substituted 1,2-Ethanediamine Ligands and Their Lithium, Aluminium, and Gallium Derivatives

Sterically demanding N,N′,N′-substituted 1,2-ethanediamine ligands have been prepared from commercially available starting materials by applying a facile one-step procedure. These ligands offer advantages compared to known systems: a suppressed delocalization due to the saturated backbone inhibits a noninnocent behaviour and the low symmetry of the related metal complexes makes them potential candidates for asymmetric catalysis. The ligands are readily transformed into the corresponding lithium derivatives 4, which in turn act as starting materials to access the corresponding aluminium and gallium dichlorides 5 and 6, respectively. In addition, deprotonation by Al(CH3)3gives rise to the related dimethylalane 7. All main-group element compounds have been studied by means of single X-ray crystallography and spectroscopic methods.

Synthesis and Cardiac Electrophysiological Activity of Aryl-Substituted Derivatives of the Class III Antiarrhythmic Agent Sematilide. Potential Class I/III Agents

Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule.Electrophysiological activity was determined b

N-(aminoalkyl)-substituted(N or C alkyl)-aryl-4(methylsulfonylamino)benzamides

N-(aminoalkyl)-substituted(N or C alkyl)-aryl-4-(methylsylfonylamino)benzamides of the formula STR1 wherein R is C1 -C4 straight chain alkyl, one of R1, R2 and R3 is a phenyl or naphthyl group and the others are hydrogen, --NR4 R5 is a secondary or teritary amino group, X and X1 are hydrogen or alkyl and n is 0 or 1, are useful as antiarrhythmic agents in the treatment of cardiac arrhythmias especially as combination Class I/Class III agents.