116861-71-3Relevant academic research and scientific papers
First total synthesis of the pavine alkaloid (±)-neocaryachine and its optical resolution
Miura, Yuta,Saito, Yohei,Goto, Masuo,Nakagawa-Goto, Kyoko
, p. 899 - 902 (2020/11/26)
The first total synthesis of (±)-neocaryachine (1) was achieved using a radical cyclization to produce the dibenzo-9-azabicyclo[3.3.1]nonane pavine skeleton, following a Bischler-Napieralski reaction to construct an intermediate benzylisoquinoline. The resulting racemic mixture was separated by chiral column chromatography to provide pure (+)- and (?)-1.
