117032-51-6

Basic information

• Product Name: 6-(N-TRIFLUOROACETYL)AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER
• Synonyms: 6-(N-TRIFLUOROACETYL)AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER;6-[(2,2,2-Trifluoroacetyl)aMino]hexanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester;N-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-2,2,2-trifluoro-acetaMide;N-[ε-trifluoroacetaMidocaproyloxy] succiniMide ester(TFCS);2,5-Dioxopyrrolidin-1-yl 6-(2,2,2-trifluoroacetamido)hexanoate
• CAS NO: 117032-51-6
• Molecular Formula: C₁₂H₁₅F₃N₂O₅
• Molecular Weight: 324.25
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents
• Mol File: 117032-51-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 70-71°C
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Ethyl Acetate
• PKA: 11.38±0.46(Predicted)
• CAS DataBase Reference: 6-(N-TRIFLUOROACETYL)AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(N-TRIFLUOROACETYL)AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER(117032-51-6)
• EPA Substance Registry System: 6-(N-TRIFLUOROACETYL)AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER(117032-51-6)

Safety Data

• Hazardous Substances Data: 117032-51-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 117032-51-6 differently. You can refer to the following data:
1. An amino reactive heterobifunctional crosslinking reagent
2. An amino reactive heterobifunctional crosslinking reagent.

Upstream product

• 74124-79-1 di(succinimido) carbonate 
• 407-91-0 6-(trifluoroacetamido)hexanoic acid 
• 5672-89-9 N-trifluoroacetoxy succinimide 
• 60-32-2 6-aminohexanoic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 851912-61-3 (2S,4R)-1-(6-aminohexanoyl)-4-hydroxy-2-(4,4′-dimethoxytrityloxymethyl)pyrrolidine 
• 1446470-39-8 C₅₄H₆₃N₄O₇P 
• 1446470-38-7 C₄₅H₄₆N₂O₆ 
• 125348-34-7 1-0-(Dimethoxytrityl)-3-N-(6-aminocaproyl)-Amino-1,2-Dihydroxypropane 

Relevant articles and documents

Pattern-based recognition of heparin contaminants by an array of self-assembling fluorescent receptors

(Figure Presented) Tracking down potential killers: Strong host-guest interactions enable the facile combination of polycationic cyclodextrin binding motifs (blue) with fluorescent reporters (orange) tethered to a hydrophobic guest molecule (dark green). An array of supramolecular fluorescent receptors prepared by this modular approach was used for the pattern-based recognition of negatively charged contaminants in the anticoagulant drug heparin.

OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION

The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

In situ formation of N-trifluoroacetoxy succinimide (TFA-NHS): One-pot formation of succinimidyl esters, N-trifluoroacetyl amino acid succinimidyl esters, and N-maleoyl amino acid succinimidyl esters

A method for the in situ formation of N-trifluoroacetoxy succinimide (TFA-NHS) and its application in the formation of succinimidyl esters is presented. The developed method provides N-trifluoroacetyl and N-maleoyl amino acid succinimidyl esters from a variety of amino acids using a one-pot, high-yielding protocol. Investigations into the formation of an N-maleoyl amino acid succinimidyl ester supported the proposal of a revised reaction mechanism, and contributed to the optimization of the reaction conditions.